Table of Contents    
SPECIAL ARTICLE
Year : 2010  |  Volume : 1  |  Issue : 2  |  Page : 94-99
 

Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research


1 The National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, United Kingdom
2 School of Veterinary Science, University of Bristol, Bristol, United Kingdom
3 School of Biological Sciences, University of Bristol, Bristol, United Kingdom
4 National Heart and Lung Institute, Imperial College London, United Kingdom
5 Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom

Date of Web Publication10-Nov-2010

Correspondence Address:
Carol Kilkenny
The National Centre for the Replacement, Refinement and Reduction of Animals in Research, London
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-500X.72351

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How to cite this article:
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother 2010;1:94-9

How to cite this URL:
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother [serial online] 2010 [cited 2021 Dec 7];1:94-9. Available from: http://www.jpharmacol.com/text.asp?2010/1/2/94/72351


In the last decade the number of bioscience journals has increased enormously, with many filling specialised niches reflecting new disciplines and technologies. The emergence of open-access journals has revolutionised the publication process, maximising the availability of research data. Nevertheless, a wealth of evidence shows that across many areas, the reporting of biomedical research is often inadequate, leading to the view that even if the science is sound, in many cases the publications themselves are not "fit for purpose," meaning that incomplete reporting of relevant information effectively renders many publications of limited value as instruments to inform policy or clinical and scientific practice. [1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21] A recent review of clinical research showed that there is considerable cumulative waste of financial resources at all stages of the research process, including as a result of publications that are unusable due to poor reporting. [22] It is unlikely that this issue is confined to clinical research. [2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[16],[17],[18],[19],[20]

Failure to describe research methods and to report results appropriately therefore has potential scientific, ethical and economic implications for the entire research process and the reputation of those involved in it. This is particularly true for animal research, one of the most controversial areas of science. The largest and most comprehensive review of published animal research undertaken to date, to our knowledge, has highlighted serious omissions in the way research using animals is reported. [5] The survey, commissioned by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), a UK Government-sponsored scientific organisation, found that only 59% of the 271 randomly chosen articles assessed stated the hypothesis or objective of the study and the number and characteristics of the animals used (i.e., species/strain, sex and age/weight). Most of the papers surveyed did not report using randomisation (87%) or blinding (86%) to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods fully described them and presented the results with a measure of precision or variability. [5] These findings are a cause for concern and are consistent with reviews of many research areas, including clinical studies, published in recent years. [2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22]


   Good Reporting is Essential for Peer Review and to Inform Future Research Top


Scrutiny by scientific peers has long been the mainstay of "quality control" for the publication process. The way that experiments are reported, in terms of the level of detail of methods and the presentation of key results, is crucial to the peer review process and, indeed, the subsequent utility and validity of the knowledge base that is used to inform future research. The onus is therefore on the research community to ensure that their research articles include all relevant information to allow in-depth critique and to avoiding duplicating studies and performing redundant experiments. Ideally scientific publications should present sufficient information to allow a knowledgeable reader to understand what was done, why and how and to assess the biological relevance of the study and the reliability and validity of the findings. There should also be enough information to allow the experiment to be repeated. [23] The problem therefore is how to ensure that all relevant information is included in research publications.


   Using Reporting Guidelines Measurably Improves the Quality of Reporting Top


Evidence provided by reviews of published research suggests that many researchers and peer reviewers would benefit from guidance about what information should be provided in a research article. The CONSORT Statement for randomised controlled clinical trials was one of the first guidelines developed in response to this need. [24],[25] Since publication, an increasing number of leading journals have supported CONSORT as part of their instructions to authors. [26],[27] As a result, convincing evidence is emerging that CONSORT improves the quality and transparency of reports of clinical trials. [28],[29]

Following CONSORT, many other guidelines have been developed-there are currently more than 90 available for reporting different types of health research, most of which have been published in the last ten years (see http://www.equator-network.org and references [30],[31] ). Guidelines have also been developed to improve the reporting of other specific bioscience research areas including metabolomics and gene expression studies. [32],[33],[34],[35],[36],[37] Several organisations support the case for improved reporting and recommend the use of reporting guidelines, including the International Committee of Medical Journal Editors, the Council of Science Editors, the Committee on Publication Ethics and the Nuffield Council for Bioethics. [38],[39],[40],[41]


   Improving the Reporting of Animal Experiments-The ARRIVE Guidelines Top


Most bioscience journals currently provide little or no guidance on what information to report when describing animal research. [42],[43],[44],[45],[46],[47],[48],[49],[50] Our review found that 4% of the 271 journal articles assessed did not report the number of animals used anywhere in the methods or the results sections. [5] Reporting animal numbers is essential so that the biological and statistical significance of the experimental results can be assessed or the data reanalysed and is also necessary if the experimental methods are to be repeated. Improved reporting of these and other details will maximise the availability and utility of the information gained from every animal and every experiment, preventing unnecessary animal use in the future. To address this, we led an initiative to produce guidelines for reporting animal research. The guidelines, referred to as ARRIVE (Animals in Research: Reporting In vivo Experiments), have been developed using the CONSORT Statement as their foundation. [24],[25]

The ARRIVE guidelines consist of a checklist of 20 items describing the minimum information that all scientific publications reporting research using animals should include, such as the number and specific characteristics of animals used (including species, strain, sex and genetic background); details of housing and husbandry; and the experimental, statistical and analytical methods (including details of methods used to reduce bias such as randomisation and blinding). All the items in the checklist have been included to promote high-quality, comprehensive reporting to allow an accurate critical review of what was done and what was found.

Consensus and consultation are the corner-stones of the guideline development process. [51] To maximise their utility, the ARRIVE guidelines have been prepared in consultation with scientists, statisticians, journal editors and research funders. We convened an expert working group, comprising researchers and statisticians from a range of disciplines and journal editors from Nature Cell Biology, Science, Laboratory Animals and the British Journal of Pharmacology (see Acknowledgments). At a one-day meeting in June 2009, the working group agreed the scope and broad content of a draft set of guidelines that were then used as the basis for a wider consultation with the scientific community, involving researchers and grant holders and representatives of the major bioscience funding bodies including the Medical Research Council, Wellcome Trust, Biotechnology and Biological Sciences Research Council and The Royal Society [Table 1] and [Table 2]. Feedback on the content and wording of the items was incorporated into the final version of the checklist. Further feedback on the content utility of the guidelines is encouraged and sought.
Table 1: Funding bodies consulted

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Table 2: Animal research: Reporting in vivo experiments: The ARRIVE guidelines

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   Improved Reporting will Maximise the Output of Published Research Top


These guidelines were developed to maximise the output from research using animals by optimising the information that is provided in publications on the design, conduct and analysis of the experiments. The need for such guidelines is further illustrated by the systematic reviews of animal research that have been carried out to assess the efficacy of various drugs and interventions in animal models. [8],[9],[13],[52],[53],[54],[55] Well-designed and -reported animal studies are the essential building blocks from which such a systematic review is constructed. The reviews have found that, in many cases, reporting omissions, in addition to the limitations of the animal models used in the individual studies assessed in the review, are a barrier to reaching any useful conclusion about the efficacy of the drugs and interventions being compared. [2],[3]

Driving improvements in reporting research using animals will require the collective efforts of authors, journal editors, peer reviewers and funding bodies. There is no single simple or rapid solution, but the ARRIVE guidelines provide a practical resource to aid these improvements. The guidelines will be published in several leading bioscience research journals simultaneously, [56],[57],[58],[59],[60] and publishers have already endorsed the guidelines by including them in their journal Instructions to Authors subsequent to publication. The NC3Rs will continue to work with journal editors to extend the range of journals adopting the guidelines and with the scientific community to disseminate the guidelines as widely as possible ( http://www.nc3rs.org.uk/ARRIVE ).


   Acknowledgments Top


The NC3Rs gratefully acknowledges the expertise and advice that all the contributors have given to developing the guidelines. We would particularly like to acknowledge the contribution of the other members of NC3Rs Reporting Guidelines Working Group (note that the working group members and authors who contributed to these guidelines were advising in their personal capacity and their input does not necessarily represent the policy of the organisations with which they are associated): Professor David Balding, Department of Epidemiology and Public Health, Imperial College, London UK; Dr Colin Dunn Editor Laboratory Animals (Royal Society of Medicine press); Dr. Stella Hurtley, Senior Editor Science; Professor Ian McGrath Editor-in-Chief British Journal of Pharmacology (Wiley Blackwell publishers); and Dr. Clare Stanford, Department of Psychopharmacology, University College, London UK. We would also like to thank NC3Rs grant holders, the Medical Research Council, Biotechnology and Biological Sciences Research Council, Wellcome Trust, Parkinson's Disease Society, British Heart Foundation and their grant holders and funding committee members who provided feedback on the guidelines; and Dr. Kathryn Chapman and Dr. Vicky Robinson (both NC3Rs) for their help with the manuscript.

 
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17 Chronic oxytocin-driven alternative splicing of Crfr2a induces anxiety
Julia Winter, Magdalena Meyer, Ilona Berger, Melanie Royer, Marta Bianchi, Kerstin Kuffner, Sebastian Peters, Simone Stang, Dominik Langgartner, Finn Hartmann, Anna K. Schmidtner, Stefan O. Reber, Oliver J. Bosch, Anna Bludau, David A. Slattery, Erwin H. van den Burg, Benjamin Jurek, Inga D. Neumann
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18 Telmisartan detection by UV spectrophotometry in mice drinking water
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19 Trimethylamine N-oxide exacerbates acetaminophen-induced liver injury by interfering with macrophage-mediated liver regeneration
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20 Inhibitory effect of roflumilast on experimental periodontitis
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21 Diet and Inflammatory Bowel Disease: What Quality Standards Should Be Applied in Clinical and Laboratory Studies?
Gerhard Rogler, Michael Scharl, Marianne Spalinger, Bahtiyar Yilmaz, Michael Zaugg, Martin Hersberger, Philipp Schreiner, Luc Biedermann, Hans Herfarth
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22 The transient receptor potential A1 ion channel (TRPA1) modifies in vivo autonomous ureter peristalsis in rats
Philipp Weinhold, Luca Villa, Frank Strittmatter, Christian Gratzke, Christian G. Stief, Fabio Castiglione, Francesco Montorsi, Petter Hedlund
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23 Assessing volume responsiveness using right ventricular dynamic indicators of preload
Michael F. Graessler, Karin H. Wodack, Hans O. Pinnschmidt, Sarah Nishimoto, Christoph R. Behem, Daniel A. Reuter, Constantin J. C. Trepte
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24 The role of postnatal estrogen deficiency on cranium dimensions
Rafaela Mariana de Lara, Matheus Caires dos Santos, Marjorie Ayumi Omori, Flares Baratto-Filho, João Armando Brancher, Paulo Nelson-Filho, Agnes Schroeder, Erika Calvano Küchler, Maria Fernanda Pioli Torres, Christian Kirschneck
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25 ERa-independent NRF2-mediated immunoregulatory activity of tamoxifen
Giovanna Pepe, Chiara Sfogliarini, Loris Rizzello, Giuseppe Battaglia, Christian Pinna, Gianenrico Rovati, Paolo Ciana, Electra Brunialti, Federica Mornata, Adriana Maggi, Massimo Locati, Elisabetta Vegeto
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26 Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2
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Biological Psychiatry. 2021; 89(11): 1045
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27 Efficacy of acute administration of inhaled argon on traumatic brain injury in mice
Federico Moro, Francesca Fossi, Aurora Magliocca, Rosaria Pascente, Eliana Sammali, Federico Baldini, Daniele Tolomeo, Edoardo Micotti, Giuseppe Citerio, Nino Stocchetti, Francesca Fumagalli, Sandra Magnoni, Roberto Latini, Giuseppe Ristagno, Elisa R. Zanier
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28 Trypanosoma cruzi infection in Cyclophilin D deficient mice
Natalia Milduberger, Patricia L. Bustos, Carolina González, Alina E. Perrone, Miriam Postan, Jacqueline Bua
Experimental Parasitology. 2021; 220: 108044
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29 Infliximab and tocilizumab reduce anxiety-like behavior, improve cognitive performance and reverse neuropathological alterations in juvenile rats with severe autoimmune arthritis
Frideriki Poutoglidou, Chryssa Pourzitaki, Maria Eleni Manthou, Athanasios Saitis, Foteini Malliou, Dimitrios Kouvelas
International Immunopharmacology. 2021; 99: 107917
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30 Recombinant human growth hormone improves the immune status of rats with septic encephalopathy: The role of VEGFR2 in the prevalence of endoplasmic reticulum stress repair module
Doaa A. Zaky, Wagdy M. Eldehna, Ahmed M. El Kerdawy, Dalaal M. Abdallah, Hanan S. El Abhar, Walaa Wadie
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31 Passive immunotherapy using chicken egg yolk antibody (IgY) against diarrheagenic E. coli: A systematic review and meta-analysis
Mukunthan Karthikeyan, Srichandrasekar Thuthikkadu Indhuprakash, Gayathri Gopal, Senthil Visaga Ambi, Uma Maheswari Krishnan, Thirumalai Diraviyam
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32 The current evidence for the treatment of sepsis with Xuebijing injection: Bioactive constituents, findings of clinical studies and potential mechanisms
Chengyu Li, Ping Wang, Min Li, Rui Zheng, Shiqi Chen, Si Liu, Zhiqiao Feng, Yongming Yao, Hongcai Shang
Journal of Ethnopharmacology. 2021; 265: 113301
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33 Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction
Lori N. Eidson, Qingzeng Gao, Hongyan Qu, Daniel S. Kikuchi, Ana Carolina P. Campos, Elizabeth A. Faidley, Yu-Yo Sun, Chia-Yi Kuan, Rosana L. Pagano, Bernard Lassègue, Malú G. Tansey, Kathy K. Griendling, Marina S. Hernandes
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34 Genetic and phenotypic analysis of the pathogenic potential of two novel Chlamydia gallinacea strains compared to Chlamydia psittaci
Marloes Heijne, Martina Jelocnik, Alexander Umanets, Michael S. M. Brouwer, Annemieke Dinkla, Frank Harders, Lucien J. M. van Keulen, Hendrik Jan Roest, Famke Schaafsma, Francisca C. Velkers, Jeanet A. van der Goot, Yvonne Pannekoek, Ad P. Koets
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35 Cochlear protection against noise exposure requires serotonin type 3A receptor via the medial olivocochlear system
Kazuya Ohata, Makoto Kondo, Yoshiyuki Ozono, Yukiko Hanada, Takashi Sato, Hidenori Inohara, Shoichi Shimada
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36 Red Blood Cells Elicit Platelet-Dependent Neutrophil Recruitment Into Lung Airspaces
Stephanie Arnold, Sajeel A. Shah, Simon J. Cleary, Blaze G. O'Shaughnessy, Richard T. Amison, Kate Arkless, Clive P. Page, Simon C. Pitchford
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37 Regulation of microRNA-221, -222, -21 and -27 in articular cartilage subjected to abnormal compressive forces
Paulina S. Stadnik, Sophie J. Gilbert, Jessica Tarn, Sarah Charlton, Andrew J. Skelton, Matthew J. Barter, Victor C. Duance, David A. Young, Emma J. Blain
The Journal of Physiology. 2021; 599(1): 143
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38 Pregnancy-related plasticity of gastric vagal afferent signals in mice
Hui Li, Georgia S. Clarke, Stewart Christie, Sharon R. Ladyman, Stephen J. Kentish, Richard L. Young, Kathryn L. Gatford, Amanda J. Page
American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 320(2): G183
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39 Oxidative Stress Profile of Mothers and Their Offspring after Maternal Consumption of High-Fat Diet in Rodents: A Systematic Review and Meta-Analysis
R. Q. Moraes-Souza, Giovana Vesentini, Verônyca Gonçalves Paula, Yuri Karen Sinzato, T. S. Soares, Rafael Bottaro Gelaleti, Gustavo Tadeu Volpato, Débora Cristina Damasceno, Gabriele Saretzki
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40 Aprepitant for Cough in Lung Cancer. A Randomized Placebo-controlled Trial and Mechanistic Insights
Jaclyn A. Smith, Amélie Harle, Rachel Dockry, Kimberley Holt, Philip Russell, Alex Molassiotis, Janelle Yorke, Ryan Robinson, Mark A. Birrell, Maria G. Belvisi, Fiona Blackhall
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41 Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1
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42 Long-term and acute safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) in juvenile and adult dogs
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43 Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study
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44 Preclinical efficacy of stem cell therapy for skin flap: a systematic review and meta-analysis
Yuan Li, Qi-lin Jiang, Leanne Van der Merwe, Dong-hao Lou, Cai Lin
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45 Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice
Victoria K. Mwaeni, James N. Nyariki, Ngalla Jillani, George Omwenga, Mathew Ngugi, Alfred Orina Isaac
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46 In-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery
Rossella Di Sapia, Federico Moro, Marica Montanarella, Valentina Iori, Edoardo Micotti, Daniele Tolomeo, Kevin K. W. Wang, Annamaria Vezzani, Teresa Ravizza, Elisa R. Zanier
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47 Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture
Sagi Enicole A Gillera, William P Marinello, Kevin T Cao, Brian M Horman, Heather M Stapleton, Heather B Patisaul
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48 Effect of Epidermal Growth Factor Treatment and Polychlorinated Biphenyl Exposure in a Dietary-Exposure Mouse Model of Steatohepatitis
Josiah E. Hardesty, Banrida Wahlang, Russell A. Prough, Kim Z. Head, Daniel Wilkey, Michael Merchant, Hongxue Shi, Jian Jin, Matthew C. Cave
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49 Impact of positive biphasic pressure during low and high inspiratory efforts in Pseudomonas aeruginosa-induced pneumonia
Daniela G. da Cruz, Raquel F. de Magalhães, Gisele A. Padilha, Mariana C. da Silva, Cassia L. Braga, Adriana R. Silva, Cassiano F. Gonçalves de Albuquerque, Vera L. Capelozzi, Cynthia S. Samary, Paolo Pelosi, Patricia R. M. Rocco, Pedro L. Silva, Michael Koval
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50 The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia
Guillermo Rodríguez-Hernández, Ana Casado-García, Marta Isidro-Hernández, Daniel Picard, Javier Raboso-Gallego, Silvia Alemán-Arteaga, Alberto Orfao, Oscar Blanco, Susana Riesco, Pablo Prieto-Matos, Francisco Javier García Criado, María Begoña García Cenador, Hanno Hock, Tariq Enver, Isidro Sanchez-Garcia, Carolina Vicente-Dueñas
Frontiers in Cell and Developmental Biology. 2021; 9
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51 Galectin-9 Regulates Monosodium Urate Crystal-Induced Gouty Inflammation Through the Modulation of Treg/Th17 Ratio
Adel Abo Mansour, Federica Raucci, Anella Saviano, Samantha Tull, Francesco Maione, Asif Jilani Iqbal
Frontiers in Immunology. 2021; 12
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52 Nerve Growth Factor Enhances Tooth Mechanical Hyperalgesia Through C-C Chemokine Ligand 19 in Rats
Rui Guo, Yiyin Chen, Lu Liu, Jing Wen, Hong Yang, Yafen Zhu, Meiya Gao, Hengyan Liang, Wenli Lai, Hu Long
Frontiers in Neurology. 2021; 12
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53 Sustainable Surface Modification of Polyetheretherketone (PEEK) Implants by Hydroxyapatite/Silica Coating—An In Vivo Animal Study
Thomas Frankenberger, Constantin Leon Graw, Nadja Engel, Thomas Gerber, Bernhard Frerich, Michael Dau
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54 Colonisation Factor CD0873, an Attractive Oral Vaccine Candidate against Clostridioides difficile
Cansu Karyal, Jaime Hughes, Michelle L. Kelly, Jeni C. Luckett, Philip V. Kaye, Alan Cockayne, Nigel P. Minton, Ruth Griffin
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55 In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds
Thaise C. Geremias, Suelen C. Sartoretto, Marcos A. Batistella, Antônio A. Ulson de Souza, Adriana T. N. N. Alves, Marcelo J.P. Uzeda, Jose Calasans-Maia, Pietro Montemezzi, Carlos Fernando de Almeida Barros Mourão, Monica Calasans-Maia
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56 Quality-Related Properties of Equine Immunoglobulins Purified by Different Approaches
Sanja Mateljak Lukacevic, Tihana Kurtovic, Maja Lang Balija, Marija Brgles, Stephanie Steinberger, Martina Marchetti-Deschmann, Beata Halassy
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57 Reg-1a Promotes Differentiation of Cortical Progenitors via Its N-Terminal Active Domain
Marjorie Varilh, Isabelle Acquatella-Tran Van Ba, Michelle Silhol, Francisco Nieto-Lopez, Mireille Moussaed, Marie-Christine Lebart, Paola Bovolenta, Jean-Michel Verdier, Mireille Rossel, Anne Marcilhac, Françoise Trousse
Frontiers in Cell and Developmental Biology. 2020; 8
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58 Protective Effect and Possible Mechanisms of Astragaloside IV in Animal Models of Diabetic Nephropathy: A Preclinical Systematic Review and Meta-Analysis
Hong Wang, Zhuang Zhuang, Yue-Yue Huang, Zhi-Zhi Zhuang, Yi Jin, Han-Yang Ye, Xiao-Ji Lin, Qun Zheng, Yi-Luan Wang
Frontiers in Pharmacology. 2020; 11
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59 The Bone Buttress Theory: The Effect of the Mechanical Loading of Bone on the Osseointegration of Dental Implants
David Chavarri-Prado, Aritza Brizuela-Velasco, Ángel Álvarez-Arenal, Markel Dieguez-Pereira, Esteban Pérez-Pevida, Iratxe Viteri-Agustín, Alejandro Estrada-Martínez
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60 Different Stages of Alveolar Bone Repair Process Are Compromised in the Type 2 Diabetes Condition: An Experimental Study in Rats
Letícia Pitol-Palin, Fábio Roberto de Souza Batista, Pedro Henrique Silva Gomes-Ferreira, Gabriel Mulinari-Santos, Edilson Ervolino, Francisley Ávila Souza, Dóris Hissako Matsushita, Roberta Okamoto
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61 Adenosine A2A and A3 Receptors as Targets for the Treatment of Hypertensive-Diabetic Nephropathy
Daniela Patinha, Carla Abreu, Carla Carvalho, Olga Mariana Cunha, Mariana Mota, Joana Afonso, Teresa Sousa, António Albino-Teixeira, Carmen Diniz, Manuela Morato
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62 Boosting the Intra-Articular Efficacy of Low Dose Corticosteroid through a Biopolymeric Matrix: An In Vivo Model of Osteoarthritis
Matilde Tschon, Francesca Salamanna, Lucia Martini, Gianluca Giavaresi, Luca Lorenzini, Laura Calzà, Milena Fini
Cells. 2020; 9(7): 1571
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63 Repurposing FDA Approved Drugs as JNK3 Inhibitor for Prevention of Neuroinflammation Induced by MCAO in Rats
Zikra Zulfiqar, Fawad Ali Shah, Shagufta Shafique, Abdullah Alattar, Tahir Ali, Arooj Mohsin Alvi, Sajid Rashid, Shupeng Li
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64 The glucosyltransferase activity of C. difficile Toxin B is required for disease pathogenesis
Terry W. Bilverstone, Megan Garland, Rory J. Cave, Michelle L. Kelly, Martina Tholen, Donna M. Bouley, Philip Kaye, Nigel P. Minton, Matthew Bogyo, Sarah A. Kuehne, Roman A. Melnyk, Bruce A. McClane
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65 Improving translatability of preclinical studies for neuromuscular disorders: lessons from the TREAT-NMD Advisory Committee for Therapeutics (TACT)
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66 The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
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67 A collagen membrane influences bone turnover marker in vivo after bone augmentation with xenogenic bone
Henning Staedt, Michael Dau, Eik Schiegnitz, Daniel G. E. Thiem, Olga Tagadiuc, Victor Palarie, Peter Ottl, Bilal Al-Nawas, Peer W. Kämmerer
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68 Does the rate of orthodontic tooth movement change during pregnancy and lactation? A systematic review of the evidence from animal studies
Moaza Omar, Eleftherios G. Kaklamanos
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69 The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Stanley E. Lazic, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Esther J. Pearl, Ole H. Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
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70 PCV cap proteins fused with calreticulin expressed into polymers in Escherichia coli with high immunogenicity in mice
Chang Liu, Yunchao Liu, Hua Feng, Baolei Zhao, Yumei Chen, Huimin Huang, Pan Wang, Ruiguang Deng, Gaiping Zhang
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71 Intermittent hypoxia reduces infarct size in rats with acute myocardial infarction: a systematic review and meta-analysis
Ke Hu, Wei Deng, Jing Yang, Yu Wei, Chaolin Wen, Xingsheng Li, Qingwei Chen, Dazhi Ke, Guiqiong Li
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72 The Quality of Reporting Raises Questions on the Experimental Validity of Animal Studies Conducted in India and Sri Lanka: Preliminary Analysis of a Systematic Survey
Vijay Pal Singh, Ayushi Jain, Shubhra Gupta, Manudharshy Vijayakumar, Kunal Pratap, Deepanshu Maheshwari, Tharanga Thoradeniya
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73 The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Stanley E. Lazic, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Esther J. Pearl, Ole H. Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
Journal of Cerebral Blood Flow & Metabolism. 2020; 40(9): 1769
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74 Antimicrobial Peptide GH12 Prevents Dental Caries by Regulating Dental Plaque Microbiota
Wentao Jiang, Yufei Wang, Junyuan Luo, Xiangshu Chen, Yuhao Zeng, Xinwei Li, Zening Feng, Linglin Zhang, Hideaki Nojiri
Applied and Environmental Microbiology. 2020; 86(14)
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75 The ARRIVE guidelines 2.0: updated guidelines for reporting animal research
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T Avey, Monya Baker, William J Browne, Alejandra Clark, Innes C Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T Holgate, David W Howells, Natasha A Karp, Stanley E Lazic, Katie Lidster, Catriona J MacCallum, Malcolm Macleod, Esther J Pearl, Ole H Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S Sena, Shai D Silberberg, Thomas Steckler, Hanno Wuerbel
BMJ Open Science. 2020; 4(1): e100115
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76 The ARRIVE guidelines 2.0: updated guidelines for reporting animal research
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Stanley E. Lazic, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Esther J. Pearl, Ole H. Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
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77 Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune-enzymatic, and gene expression analysis
Andréia Manetta Molez, Eduarda Helena Leandro Nascimento, Francisco Haiter Neto, Fabiano Ribeiro Cirano, Suzana Peres Pimentel, Fernanda Vieira Ribeiro, Marcio Zaffalon Casati, Mônica Grazieli Corrêa
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78 Effect of ovariectomy on maxilla and mandible dimensions of female rats
Marjorie Ayumi Omori, Guido Artemio Marañón-Vásquez, Priscilla Coutinho Romualdo, Evandro Carneiro Martins Neto, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto, Paulo Nelson-Filho, Peter Proff, Jorge Esquiche León, Christian Kirschneck, Erika C. Küchler
Orthodontics & Craniofacial Research. 2020; 23(3): 342
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79 Research waste-related editorial policies of leading dental journals: Situation 2018
Bushra S. Almaqrami, Fang Hua, Yanxiaoxue Liu, Hong He
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80 The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Stanley E. Lazic, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Esther J. Pearl, Ole H. Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
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81 Modulatory effect of methanandamide on gastric vagal afferent satiety signals depends on nutritional status
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The Journal of Physiology. 2020; 598(11): 2169
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82 Akhirin regulates the proliferation and differentiation of neural stem cells/progenitor cells at neurogenic niches in mouse brain
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83 Differential hepatoprotective role of the cannabinoid CB 1 and CB 2 receptors in paracetamol-induced liver injury
Patricia Rivera, Antonio Vargas, Antoni Pastor, Anna Boronat, Antonio Jesús López-Gambero, Laura Sánchez-Marín, Dina Medina-Vera, Antonia Serrano, Francisco Javier Pavón, Rafael Torre, Ekaitz Agirregoitia, María Isabel Lucena, Fernando Rodríguez de Fonseca, Juan Decara, Juan Suárez
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84 Transgenic LQT2, LQT5, and LQT2-5 rabbit models with decreased repolarisation reserve for prediction of drug-induced ventricular arrhythmias
Tibor Hornyik, Alessandro Castiglione, Gerlind Franke, Stefanie Perez-Feliz, Péter Major, László Hiripi, Gideon Koren, Zsuzsanna Bosze, András Varró, Manfred Zehender, Michael Brunner, Christoph Bode, István Baczkó, Katja E. Odening
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85 Mechanisms of artemether toxicity on single cardiomyocytes and protective effect of nanoencapsulation
Ana Carolina Moreira Souza, Andrea Grabe-Guimarães, Jader dos Santos Cruz, Artur Santos-Miranda, Charlotte Farah, Liliam Teixeira Oliveira, Alexandre Lucas, Franck Aimond, Pierre Sicard, Vanessa Carla Furtado Mosqueira, Sylvain Richard
British Journal of Pharmacology. 2020;
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86 The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia, Sabina Alam, Marc T. Avey, Monya Baker, William J. Browne, Alejandra Clark, Innes C. Cuthill, Ulrich Dirnagl, Michael Emerson, Paul Garner, Stephen T. Holgate, David W. Howells, Natasha A. Karp, Stanley E. Lazic, Katie Lidster, Catriona J. MacCallum, Malcolm Macleod, Esther J. Pearl, Ole H. Petersen, Frances Rawle, Penny Reynolds, Kieron Rooney, Emily S. Sena, Shai D. Silberberg, Thomas Steckler, Hanno Würbel
British Journal of Pharmacology. 2020; 177(16): 3617
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87 Hypersensitivity to amphetamine's psychomotor and reinforcing effects in serotonin transporter knockout rats: Glutamate in the nucleus accumbens
Lucia Caffino, Michel M. M. Verheij, Karine Roversi, Giorgia Targa, Francesca Mottarlini, Piotr Popik, Agnieska Nikiforuk, Joanna Golebiowska, Fabio Fumagalli, Judith R. Homberg
British Journal of Pharmacology. 2020;
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88 Improving natural product research translation: From source to clinical trial
Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss, Naomi K. Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N. Brown, Frederic D. Bushman, Steven J. Casper, Floyd H. Chilton, Christopher S. Coffey, Mario G. Ferruzzi, D. Craig Hopp, Mairead Kiely, Daniel Lakens, John B. MacMillan, David O. Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K. Quinney, Barbara Rehermann, Kenneth D. R. Setchell, Nisha S. Sipes, Jacqueline M. Stephens, D. Lansing Taylor, Hervé Tiriac, Michael A. Walters, Dan Xi, Giovanna Zappalá, Guido F. Pauli
The FASEB Journal. 2020; 34(1): 41
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89 Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model
R. M. Huebinger, D. H. Do, D. L. Carlson, X. Yao, D. H. Stones, M. De Souza Santos, D. P. Vaz, E. Keen, S. E. Wolf, JP Minei, K. P. Francis, K. Orth, A. M. Krachler
Virulence. 2020; 11(1): 695
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90 Integrin a?ß3 modulates lipopolysaccharide-induced hyperpermeability in cardiac microvascular endothelial cells
Li Li, Zhou Rongfang, Zhen Junhai, Chen Changqin, Yan Jing
Bioscience, Biotechnology, and Biochemistry. 2020; 84(8): 1614
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91 Blockade of IL-6 signaling prevents paclitaxel-induced neuropathy in C57Bl/6 mice
Petra Huehnchen, Hannah Muenzfeld, Wolfgang Boehmerle, Matthias Endres
Cell Death & Disease. 2020; 11(1)
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92 nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
Hai-Ying Liang, Zhi-Jin Chen, Hui Xiao, Yu-Hui Lin, Ying-Yi Hu, Lei Chang, Hai-Yin Wu, Peng Wang, Wei Lu, Dong-Ya Zhu, Chun-Xia Luo
Nature Communications. 2020; 11(1)
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93 Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action
Mohamed Fares, Wagdy M. Eldehna, Silvia Bua, Cecilia Lanzi, Laura Lucarini, Emanuela Masini, Thomas S. Peat, Hatem A. Abdel-Aziz, Alessio Nocentini, Paul A. Keller, Claudiu T. Supuran
Journal of Medicinal Chemistry. 2020; 63(6): 3317
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94 Reporting guidelines of health research studies are frequently used inappropriately
Lisa Caulley, Ferrán Catalá-López, Jonathan Whelan, Michel Khoury, Jennifer Ferraro, Wei Cheng, Don Husereau, Douglas G. Altman, David Moher
Journal of Clinical Epidemiology. 2020; 122: 87
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95 H2S donor GYY4137 ameliorates paclitaxel-induced neuropathic pain in mice
Bedoor Qabazard, Willias Masocha, Maitham Khajah, Oludotun Adebayo Phillips
Biomedicine & Pharmacotherapy. 2020; 127: 110210
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96 Botulinum toxin A alleviates orofacial nociception induced by orthodontic tooth movement through nociceptin/orphanin-FQ pathway in rats
Jiahong Lyu, Jing Wen, Rui Guo, Yafen Zhu, Hengyan Liang, Meiya Gao, Hang Wang, Wenli Lai, Hu Long
Archives of Oral Biology. 2020; 117: 104817
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97 Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice
Kai Wang, Martin Yan-Chun Chan, Jian Xu, Pik-Shan Li, Xing Liu, Angus Yiu-Fai Lee, Susanna Sau-Tuen Lee, Wing-Tai Cheung
Transgenic Research. 2020; 29(5-6): 499
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98 Omega-3 offers better hypothalamus protection by decreasing POMC expression and elevating ghrelin hormone: a prospective trial to overcome methotrexate-induced anorexia
Heba Mostafa, Lamia Barakat, Walied S. Abdo, Rania M. Khalil
Endocrine. 2020; 69(2): 358
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99 High Glucose-Aggravated Hepatic Insulin Resistance: Role of the NLRP3 Inflammasome in Kupffer Cells
Tao Zheng, Qibin Wang, Yongcheng Dong, Weidong Ma, Yonghong Zhang, Yan Zhao, Fang Bian, Li Chen
Obesity. 2020; 28(7): 1270
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100 Influence of collagen membrane on bone quality in titanium mesh reconstructions—Study in rats
Cristine D'Almeida Borges, Paulo Esteves Pinto Faria, Paula Gabriela Faciola Pessôa de Oliveira, Mariana Sales de Melo Soares, Milla Sprone Tavares Ricoldi, Monalisa Sena Costa, Arthur Belém Novaes Júnior, Paulo Tambasco de Oliveira, Mário Taba Júnior
Journal of Periodontology. 2020; 91(12): 1673
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101 Collagen membranes of dermal and pericardial origin—In vivo evolvement of vascularization over time
Michael Dau, Lisann Volprich, Eberhard Grambow, Brigitte Vollmar, Bernhard Frerich, Bilal Al-Nawas, Peer W. Kämmerer
Journal of Biomedical Materials Research Part A. 2020; 108(12): 2368
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102 The effects of oral arginine on its metabolic pathways in Sprague–Dawley rats
Sarah Martin, Kaushik Desai
British Journal of Nutrition. 2020; 123(2): 135
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103 Effect of dietary supplementation of pyrroloquinoline quinone disodium on growth performance, meat quality and antioxidative ability of broilers
Guo-qing LIU, Guang-ming SUN, Xiu-dong LIAO, Jian-zhong HUANG, Mei-jin GUO, Li-yang ZHANG, Yan-li GUO, Lin LU, Xu-gang LUO
Journal of Integrative Agriculture. 2020; 19(7): 1850
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104 Alterations in mouse spinal cord and sciatic nerve microRNAs after the chronic constriction injury (CCI) model of neuropathic pain
Jenny L. Wilkerson, Jinmai Jiang, Jasmine S. Felix, Julie K. Bray, Lais da Silva, Raad Z. Gharaibeh, Lance R. McMahon, Thomas D. Schmittgen
Neuroscience Letters. 2020; 731: 135029
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105 Modulation of endoplasmic reticulum stress response in gut-origin encephalopathy: Impact of vascular endothelial growth factor receptor-2 manipulation
Doaa A. Zaky, Walaa Wadie, Wagdy M. Eldehna, Ahmed M. El Kerdawy, Dalaal M. Abdallah, Hanan S. El Abhar
Life Sciences. 2020; 252: 117654
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106 Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
Jahedul Alam, Moses Musiime, Andreas Romaine, Mugdha Sawant, Arne Olav Melleby, Ning Lu, Beate Eckes, Geir Christensen, Donald Gullberg
Matrix Biology Plus. 2020; 8: 100045
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107 Fetal programming by high-fat diet promoted the decreased of the prostate in adult Wistar albino rats
Pamella Campos-Silva, Angelo Fernandes, Waldemar Costa, Francisco Jose Sampaio, Bianca Gregorio
Mechanisms of Development. 2020; 164: 103649
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108 Dietary ?3-and ?6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice
Wilhelm Stoffel, Inga Schmidt-Soltau, Erika Binczek, Andreas Thomas, Mario Thevis, Ina Wegner
Molecular Metabolism. 2020; 36: 100974
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109 Application of the UV–vis spectrophotometry method for the determination of glutamate in the cerebrospinal fluid of rats
Cirley Pinheiro Ferreira, Flavia Tasmim Techera Antunes, Isadora Nunes Rebelo, Claudio Antônio da Silva, Fernanda Nunes Vilanova, Dione Silva Corrêa, Alessandra Hubner de Souza
Journal of Pharmaceutical and Biomedical Analysis. 2020; 186: 113290
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110 Substitution of high-dose sucrose with fructose in high-fat diets resulted in higher plasma concentrations of aspartic acid, cystine, glutamic acid, ornithine and phenylalanine, and higher urine concentrations of arginine and citrulline
Alexander Krokedal Rønnevik, Oddrun Anita Gudbrandsen
Nutrition Research. 2020; 79: 100
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111 High fat diet induced obesity alters endocannabinoid and ghrelin mediated regulation of components of the endocannabinoid system in nodose ganglia
Stewart Christie, Rebecca O’Rielly, Hui Li, Gary A. Wittert, Amanda J. Page
Peptides. 2020; 131: 170371
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112 A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3ß(Ser9)-mediated Nrf2 activation
Sha Liao, Jingni Wu, Ruimin Liu, Shixiang Wang, Jing Luo, Yang Yang, Yannan Qin, Tao Li, Xiaopu Zheng, Jing Song, Xinfeng Zhao, Chaoni Xiao, Yajun Zhang, Liujiao Bian, Pu Jia, Yajun Bai, Xiaohui Zheng
Redox Biology. 2020; 36: 101644
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113 A preclinical randomized controlled study of ischemia treated with Ginkgo biloba extracts: Are complex components beneficial for treating acute stroke?
Wen Dong, Shunying Zhao, Shaohong Wen, Chengya Dong, Qingfang Chen, Ting Gong, Wentao Chen, Wenqian Liu, Liting Mu, Honglin Shan, Xiaoxuan Xie, Xiangrong Liu
Current Research in Translational Medicine. 2020; 68(4): 197
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114 Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate
Li Tao, Zhuangzhuang Jiang, Min Xu, Tingting Xu, Yanqing Liu
Chemical Research in Toxicology. 2019; 32(12): 2526
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115 Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01
Guillem Pascual-Pasto, Miriam Bazan-Peregrino, Nagore G. Olaciregui, Camilo A. Restrepo-Perdomo, Ana Mato-Berciano, Daniela Ottaviani, Klaus Weber, Genoveva Correa, Sonia Paco, Monica Vila-Ubach, Maria Cuadrado-Vilanova, Helena Castillo-Ecija, Gaia Botteri, Laura Garcia-Gerique, Helena Moreno-Gilabert, Marta Gimenez-Alejandre, Patricia Alonso-Lopez, Marti Farrera-Sal, Silvia Torres-Manjon, Dolores Ramos-Lozano, Rafael Moreno, Isabelle Aerts, François Doz, Nathalie Cassoux, Elodie Chapeaublanc, Montserrat Torrebadell, Monica Roldan, Andrés König, Mariona Suñol, Joana Claverol, Cinzia Lavarino, Torres Carmen de, Ligia Fu, François Radvanyi, Francis L. Munier, Jaume Catalá-Mora, Jaume Mora, Ramón Alemany, Manel Cascalló, Guillermo L. Chantada, Angel M. Carcaboso
Science Translational Medicine. 2019; 11(476)
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116 Hard Tissue Augmentation of Aged Bone by Means of a Tin-Free PLLA-PCL Co-Polymer Exhibiting in vivo Anergy and Long-Term Structural Stability
Magdalena M. Schimke, Swaraj Paul, Katharina Tillmann, Günter Lepperdinger, Robert G. Stigler
Gerontology. 2019; 65(2): 174
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117 Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ?3- and ?6-long-chain-PUFA deficiency
Ina Hammels, Erika Binczek, Inga Schmidt-Soltau, Britta Jenke, Andreas Thomas, Matthias Vogel, Mario Thevis, Dilyana Filipova, Symeon Papadopoulos, Wilhelm Stoffel
Journal of Lipid Research. 2019; 60(8): 1396
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118 Study Design Rigor in Animal-Experimental Research Published in Anesthesia Journals
Janine M. Hoerauf,Angela F. Moss,Ana Fernandez-Bustamante,Karsten Bartels
Anesthesia & Analgesia. 2018; 126(1): 217
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119 Variable Ventilation Associated With Recruitment Maneuver Minimizes Tissue Damage and Pulmonary Inflammation in Anesthetized Lung-Healthy Rats
Luciana Moisés Camilo,Gabriel Casulari Motta-Ribeiro,Mariana Barcellos de Ávila,Luis Felipe Santos Cruz Paula,Mariana Boechat de Abreu,Alysson Roncally Carvalho,Walter Araujo Zin
Anesthesia & Analgesia. 2018; 127(3): 784
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120 Safety of lotilaner flavoured chewable tablets (CredelioTM) after oral administration in cats
Emmanuelle A. Kuntz,Srinivas Kammanadiminti
Parasites & Vectors. 2018; 11(1)
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121 Improved functional outcome after chronic stroke with delayed anti-Nogo-A therapy: A clinically relevant intention-to-treat analysis
Katherine M Podraza,Yasmin Mehta,Vicki A Husak,Elise Lippmann,Timothy E OæBrien,Gwendolyn L Kartje,Shih-Yen Tsai
Journal of Cerebral Blood Flow & Metabolism. 2018; 38(8): 1327
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122 Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia
Pavlina Janovska,Jan Verner,Jiri Kohoutek,Lenka Bryjova,Michaela Gregorova,Marta Dzimkova,Hana Skabrahova,Tomasz Radaszkiewicz,Petra Ovesna,Olga Vondalova Blanarova,Tereza Nemcova,Zuzana Hoferova,Katerina Vasickova,Lucie Smyckova,Alexander Egle,Sarka Pavlova,Lucie Poppova,Karla Plevova,Sarka Pospisilova,Vitezslav Bryja
Blood. 2018; 131(11): 1206
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123 BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer
Dennis O. Adeegbe, Shengwu Liu, Maureen M. Hattersley, Michaela Bowden, Chensheng W. Zhou, Shuai Li, Raven Vlahos, Michael Grondine, Igor Dolgalev, Elena V. Ivanova, Max M. Quinn, Peng Gao, Peter S. Hammerman, James E. Bradner, J. Alan Diehl, Anil K. Rustgi, Adam J. Bass, Aristotelis Tsirigos, Gordon J. Freeman, Huawei Chen, Kwok-Kin Wong
Cancer Immunology Research. 2018; 6(10): 1234
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124 Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
Zebin Wang, Shaun E. Grosskurth, Tony Cheung, Philip Petteruti, Jingwen Zhang, Xin Wang, Wenxian Wang, Farzin Gharahdaghi, Jiaquan Wu, Nancy Su, Ryan T. Howard, Michele Mayo, Dan Widzowski, David A. Scott, Jeffrey W. Johannes, Michelle L. Lamb, Deborah Lawson, Jonathan R. Dry, Paul D. Lyne, Edward W. Tate, Michael Zinda, Keith Mikule, Stephen E. Fawell, Corinne Reimer, Huawei Chen
Cancer Research. 2018; 78(23): 6691
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125 Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model
Ebba Beller,Laura Reuter,Anne Kluge,Christine Preibisch,Ute Lindauer,Alexei Bogdanov,Friederike Lämmer,Claire Delbridge,Kaspar Matiasek,Benedikt J. Schwaiger,Tobias Boeckh-Behrens,Claus Zimmer,Alexandra S. Gersing
Scientific Reports. 2018; 8(1)
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126 Fingolimod therapy is not effective in a mouse model of spontaneous autoimmune peripheral polyneuropathy
Petra Huehnchen,Wolfgang Boehmerle,Matthias Endres
Scientific Reports. 2018; 8(1)
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127 Detection of thoracic vascular structures by electrical impedance tomography: a systematic assessment of prominence peak analysis of impedance changes
K H Wodack,S Buehler,S A Nishimoto,M F Graessler,C R Behem,A D Waldmann,B Mueller,S H Böhm,E Kaniusas,F Thürk,A Maerz,C J C Trepte,D A Reuter
Physiological Measurement. 2018; 39(2): 024002
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128 Longitudinal MRI analysis and histological characterization after spinal cord injury in two mouse strains with different functional recovery: gliosis as a key factor
Harun Najib NORISTANI,Guillaume Patrick SAINT-MARTIN,Maida CARDOSO,Rahima SIDIBOULENOUAR,Mathias CATTEAU,Christophe COILLOT,Christophe GOZE-BAC,Florence Evelyne Perrin
Journal of Neurotrauma. 2018;
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129 Scaffold-Based Temporomandibular Joint Tissue Regeneration in Experimental Animal Models: A Systematic Review
Espen Helgeland,Siddharth Shanbhag,Torbjørn Ostvik Pedersen,Kamal Mustafa,Annika Rosén
Tissue Engineering Part B: Reviews. 2018;
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130 Does common prescription medication affect the rate of orthodontic tooth movement? A systematic review
Miltiadis A Makrygiannakis,Eleftherios G Kaklamanos,Athanasios E Athanasiou
European Journal of Orthodontics. 2018;
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131 Effects of the antagomiRs 15b and 200b on the altered healing pattern of diabetic mice
Gabriele Pizzino,Natasha Irrera,Federica Galfo,Giovanni Pallio,Federica Mannino,Angelica Dæamore,Enrica Pellegrino,Antonio Ieni,Giuseppina T Russo,Marco Calapai,Domenica Altavilla,Francesco Squadrito,Alessandra Bitto
British Journal of Pharmacology. 2018; 175(4): 644
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132 In vitro and in vivo effects of MK2206 and chloroquine combination therapy on endometriosis: autophagy may be required for regrowth of endometriosis
Sachiko Matsuzaki,Jean-Luc Pouly,Michel Canis
British Journal of Pharmacology. 2018; 175(10): 1637
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133 Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord
Bryony L Winters,Tristan Rawling,Robert J Vandenberg,Macdonald J Christie,Rebecca F Bhola,Wendy L Imlach
British Journal of Pharmacology. 2018;
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134 Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition
Vivek Krishna Pulakazhi Venu,Mahmoud Saifeddine,Koichiro Mihara,Mahmoud El-Daly,Darrell Belke,Jonathan L E Dean,Edward R OæBrien,Simon A Hirota,Morley D Hollenberg
British Journal of Pharmacology. 2018;
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135 Boosting phagocytosis and anti-inflammatory phenotype in microglia mediates neuroprotection by PPAR? agonist MDG548 in Parkinsonæs disease models
Daniela Lecca,Elzbieta Janda,Giovanna Mulas,Andrea Diana,Concetta Martino,Fabrizio Angius,Stefano Spolitu,Maria Antonietta Casu,Gabriella Simbula,Laura Boi,Barbara Batetta,Saturnino Spiga,Anna R Carta
British Journal of Pharmacology. 2018;
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136 The selective mineralocorticoid receptor antagonist eplerenone prevents decompensation of the liver in cirrhosis
Barbara Schreier,Anja Wolf,Stefanie Hammer,Sabine Pohl,Sigrid Mildenberger,Sindy Rabe,Michael Gekle,Alexander Zipprich
British Journal of Pharmacology. 2018;
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137 The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction
Scarlett Gillespie,Paul M Holloway,Felix Becker,Francesca Rauzi,Shantel A Vital,Kirk A Taylor,Karen Y Stokes,Michael Emerson,Felicity N E Gavins
British Journal of Pharmacology. 2018;
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138 Effects of cannabidiol plus naltrexone on motivation and ethanol consumption
Adrián Viudez-Martínez,María S García-Gutiérrez,Ana Isabel Fraguas-Sánchez,Ana Isabel Torres-Suárez,Jorge Manzanares
British Journal of Pharmacology. 2018;
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139 Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration-approved drugs
Hui-Ping Lin,Bhupesh Singla,Pushpankur Ghoshal,Jessica L Faulkner,Mary Cherian-Shaw,Paul M OæConnor,Jin-Xiong She,Eric J Belin de Chantemele,Gábor Csányi
British Journal of Pharmacology. 2018;
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140 Peripheral Muscle Near-Infrared Spectroscopy Variables are Altered Early in Septic Shock
Diego Orbegozo,Fuhong Su,Keliang Xie,Lokmane Rahmania,Fabio Silvio Taccone,Daniel De Backer,Jean-Louis Vincent,Jacques Creteur
SHOCK. 2018; 50(1): 87
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141 Effects of environmental temperature and dietary zinc on egg production performance, egg quality and antioxidant status and expression of heat-shock proteins in tissues of broiler breeders
Xiudong Liao,Wenxiang Li,Yongwen Zhu,Liyang Zhang,Lin Lu,Xi Lin,Xugang Luo
British Journal of Nutrition. 2018; 120(01): 3
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142 Virgin olive oil and its phenol fraction modulate monocyte/macrophage functionality: a potential therapeutic strategy in the treatment of systemic lupus erythematosus
Marina Aparicio-Soto,Sergio Montserrat-de la Paz,Marina Sanchez-Hidalgo,Ana Cardeno,Beatriz Bermudez,Francisco J. G. Muriana,Catalina Alarcon-de-la-Lastra
British Journal of Nutrition. 2018; : 1
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143 Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Management of Rheumatoid Arthritis
Ozlem Akgul,Lorenzo Di Cesare Mannelli,Daniela Vullo,Andrea Angeli,Carla Ghelardini,Gianluca Bartolucci,Abdulmalik Saleh Alfawaz Altamimi,Andrea Scozzafava,Claudiu T. Supuran,Fabrizio Carta
Journal of Medicinal Chemistry. 2018;
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144 Discovery of ß-Adrenergic Receptors Blocker–Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy
Alessio Nocentini,Mariangela Ceruso,Silvia Bua,Carrie L. Lomelino,Jacob T. Andring,Robert McKenna,Cecilia Lanzi,Silvia Sgambellone,Riccardo Pecori,Rosanna Matucci,Luca Filippi,Paola Gratteri,Fabrizio Carta,Emanuela Masini,Silvia Selleri,Claudiu T. Supuran
Journal of Medicinal Chemistry. 2018;
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145 BRD4 facilitates replication stress-induced DNA damage response
Jingwen Zhang,Austin M. Dulak,Maureen M. Hattersley,Brandon S. Willis,Jenni Nikkilä,Anderson Wang,Alan Lau,Corinne Reimer,Michael Zinda,Stephen E. Fawell,Gordon B. Mills,Huawei Chen
Oncogene. 2018;
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146 Cylindromatosis mediates neuronal cell death in vitro and in vivo
Goutham K. Ganjam,Nicole Angela Terpolilli,Sebastian Diemert,Ina Eisenbach,Lena Hoffmann,Christina Reuther,Christiane Herden,Joachim Roth,Nikolaus Plesnila,Carsten Culmsee
Cell Death & Differentiation. 2018;
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147 Review: Assessing fish welfare in research and aquaculture, with a focus on European directives
M. Toni,A. Manciocco,E. Angiulli,E. Alleva,C. Cioni,S. Malavasi
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148 Bacteria-Carried Iron Oxide Nanoparticles for Treatment of Anemia
Víctor Garcés,Alba Rodríguez-Nogales,Ana González,Natividad Gálvez,M. Elena Rodríguez-Cabezas,María L. García-Martin,Lucia Gutiérrez,Deyanira Rondón,Mónica Olivares,Julio Gálvez,Jose M. Dominguez-Vera
Bioconjugate Chemistry. 2018; 29(5): 1785
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149 A transcriptome comparison of time-matched developing human, mouse and rat neural progenitor cells reveals human uniqueness
Stefan Masjosthusmann,Daniel Becker,Barbara Petzuch,Jördis Klose,Clara Siebert,Rene Deenen,Marta Barenys,Jenny Baumann,Katharina Dach,Julia Tigges,Ulrike Hübenthal,Karl Köhrer,Ellen Fritsche
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150 Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits
Anna Cavaccini,Marta Gritti,Andrea Giorgi,Andrea Locarno,Nicolas Heck,Sara Migliarini,Alice Bertero,Maddalena Mereu,Giulia Margiani,Massimo Trusel,Tiziano Catelani,Roberto Marotta,Maria Antonietta De Luca,Jocelyne Caboche,Alessandro Gozzi,Massimo Pasqualetti,Raffaella Tonini
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151 Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation
Nadine Gehrke,Nadine Hövelmeyer,Ari Waisman,Beate K. Straub,Julia Weinmann-Menke,Marcus A. Wörns,Peter R. Galle,Jörn M. Schattenberg
Journal of Hepatology. 2018;
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152 Medial prefrontal cortex TRPV1 and CB1 receptors modulate cardiac baroreflex activity by regulating the NMDA receptor/nitric oxide pathway
Davi C. Lagatta,Luciana B. Kuntze,Nilson C. Ferreira-Junior,Leonardo B. M. Resstel
Pflügers Archiv - European Journal of Physiology. 2018;
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153 Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
David Martín-Hernández,Hiram Tendilla-Beltrán,José L. M. Madrigal,Borja García-Bueno,Juan C. Leza,Javier R. Caso
Molecular Neurobiology. 2018;
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154 Effects of the highly COX-2-selective analgesic NSAID etoricoxib on the rate of orthodontic tooth movement and cranial growth
Christian Kirschneck,Erika Calvano Küchler,Ulrich Wahlmann,Peter Proff,Agnes Schröder
Annals of Anatomy - Anatomischer Anzeiger. 2018; 220: 21
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155 Influence of nicotine on orthodontic tooth movement: A systematic review of experimental studies in rats
Dimitrios Michelogiannakis,P. Emile Rossouw,Deema Al-Shammery,Zohaib Akram,Junad Khan,Georgios E. Romanos,Fawad Javed
Archives of Oral Biology. 2018; 93: 66
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156 Behavioral testing and litter effects in the rabbit
G. Gümüs,A.A. Agyemang,O. Romantsik,R. Sandgren,H. Karlsson,M. Gram,S. Vallius,D. Ley,D.L.A. van den Hove,M. Bruschettini
Behavioural Brain Research. 2018;
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157 Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation
Martine Catharina Josephine Hofmann,Mike Schmidt,Olga Arne,Gerd Geisslinger,Michael John Parnham,Natasja Maria Wilhelmina Johanna de Bruin
Journal of Dermatological Science. 2018;
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158 Isoflurane and the Analgesic Effect of Acupuncture and Electroacupuncture in an Animal Model of Neuropathic Pain
Lauren Naomi Spezia Adachi,Rafael Vercelino,Carla de Oliveira,Vanessa Leal Scarabelot,Andressa de Souza,Liciane Fernandes Medeiros,Stefania Giotti Cioato,Wolnei Caumo,Iraci L.S. Torres
Journal of Acupuncture and Meridian Studies. 2018;
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159 Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides
Shaobin Yang,Sònia Pascual-Guiral,Rebeca Ponce,Lydia Giménez-Llort,María A. Baltrons,Ottavio Arancio,Jose R. Palacio,Victoria M. Clos,Victor J. Yuste,Jose R. Bayascas
Frontiers in Aging Neuroscience. 2018; 9
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160 Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice
Zhenbo Huang,Carlie A. Hoffman,Brandon M. Chelette,Nicolas Thiebaud,Debra A. Fadool
Frontiers in Behavioral Neuroscience. 2018; 12
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161 Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development
Xiaozhi Bai,Ting He,Yang Liu,Julei Zhang,Xiaoqiang Li,Jihong Shi,Kejia Wang,Fu Han,Wei Zhang,Yijie Zhang,Weixia Cai,Dahai Hu
Frontiers in Immunology. 2018; 9
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162 The role of focal adhesion kinase in transforming growth factor-ß2 induced migration of human lens epithelial cells
Jie Liu, Dan Xu, Jingming Li, Ning Gao, Chongbing Liao, Ruihua Jing, Bogang Wu, Bo Ma, Yongping Shao, Cheng Pei
International Journal of Molecular Medicine. 2018;
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163 Impact of Nano-Crystalline Diamond Enhanced Hydrophilicity on Cell Proliferation on Machined and SLA Titanium Surfaces: An In-Vivo Study in Rodents
Robert Stigler,Kathrin Becker,Michela Bruschi,Doris Steinmüller-Nethl,Robert Gassner
Nanomaterials. 2018; 8(7): 524
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164 Sinomenine alleviates dextran sulfate sodium-induced colitis via the Nrf2/NQO-1 signaling pathway
Yan Zhou, Hanyang Liu, Jun Song, Liang Cao, Liming Tang, Chunjian Qi
Molecular Medicine Reports. 2018;
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165 Evaluation of a hydrogel membrane on bone regeneration in furcation periodontal defects in dogs
Xavier STRUILLOU,Aurélien FRUCHET,Mia RAKIC,Zahi BADRAN,Gildas RETHORE,Sophie SOURICE,Borhane Hakim FELLAH,Laurent LE GUEHENNEC,Olivier GAUTHIER,Pierre WEISS,Assem SOUEIDAN
Dental Materials Journal. 2018;
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166 Periodontal Tissue Regeneration Using Syngeneic Adipose-Derived Stromal Cells in a Mouse Model
Mathieu Lemaitre,Paul Monsarrat,Vincent Blasco-Baque,Pascale Loubières,Rémy Burcelin,Louis Casteilla,Valérie Planat-Bénard,Philippe Kémoun
STEM CELLS Translational Medicine. 2017; 6(2): 656
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167 The Frequency-Dependent Aerobic Exercise Effects of Hypothalamic GABAergic Expression and Cardiovascular Functions in Aged Rats
Yan Li,Ziqi Zhao,Jiajia Cai,Boya Gu,Yuanyuan Lv,Li Zhao
Frontiers in Aging Neuroscience. 2017; 9
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168 Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear
Mitsuo P. Sato,Taiga Higuchi,Fumiaki Nin,Genki Ogata,Seishiro Sawamura,Takamasa Yoshida,Takeru Ota,Karin Hori,Shizuo Komune,Satoru Uetsuka,Samuel Choi,Masatsugu Masuda,Takahisa Watabe,Sho Kanzaki,Kaoru Ogawa,Hidenori Inohara,Shuichi Sakamoto,Hirohide Takebayashi,Katsumi Doi,Kenji F. Tanaka,Hiroshi Hibino
Frontiers in Molecular Neuroscience. 2017; 10
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169 Shexiang Baoxin Pills for Coronary Heart Disease in Animal Models: Preclinical Evidence and Promoting Angiogenesis Mechanism
Ke-Jian Zhang,Jia-Zhen Zhu,Xiao-Yi Bao,Qun Zheng,Guo-qing Zheng,Yan Wang
Frontiers in Pharmacology. 2017; 8
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170 Kininase 1 As a Preclinical Therapeutic Target for Kinin B1 Receptor in Insulin Resistance
Youssef Haddad,Réjean Couture
Frontiers in Pharmacology. 2017; 8
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171 Effects of Simvastatin Beyond Dyslipidemia: Exploring Its Antinociceptive Action in an Animal Model of Complex Regional Pain Syndrome-Type I
Graziela Vieira,Juliana Cavalli,Elaine C. D. Gonçalves,Tainara R. Gonçalves,Larissa R. Laurindo,Maíra Cola,Rafael C. Dutra
Frontiers in Pharmacology. 2017; 8
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172 RgIA4 Potently Blocks Mouse a9a10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia
Sean B. Christensen,Arik J. Hone,Isabelle Roux,Julie Kniazeff,Jean-Philippe Pin,Grégory Upert,Denis Servent,Elisabeth Glowatzki,J. Michael McIntosh
Frontiers in Cellular Neuroscience. 2017; 11
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173 Localization and Interaction between Kinin B1 Receptor and NADPH Oxidase in the Vascular System of Diabetic Rats
Youssef Haddad,Réjean Couture
Frontiers in Physiology. 2017; 8
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174 Exercise-induced effects on UCP1 expression in classical brown adipose tissue: a systematic review
Andreas D. Flouris,Petros C. Dinas,Angelica Valente,Cláudia Marlise Balbinotti Andrade,Nair Honda Kawashita,Paraskevi Sakellariou
Hormone Molecular Biology and Clinical Investigation. 2017; 31(2)
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175 Mast Cell Coupling to the Kallikrein–Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease
Clarissa R. Nascimento,Daniele Andrade,Carla Eponina Carvalho-Pinto,Rafaela Rangel Serra,Lucas Vellasco,Guilherme Brasil,Erivan Schnaider Ramos-Junior,Julia Barbalho da Mota,Larissa Nogueira Almeida,Marcus V. Andrade,Maria de Nazaré Correia Soeiro,Luiz Juliano,Patrícia Hessab Alvarenga,Ana Carolina Oliveira,Fernando Lencastre Sicuro,Antônio C. Campos de Carvalho,Erik Svensjö,Julio Scharfstein
Frontiers in Immunology. 2017; 8
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176 Arthritic role of Porphyromonas gingivalis in collagen-induced arthritis mice
Hyerin Jung,Seung Min Jung,Yeri Alice Rim,Narae Park,Yoojun Nam,Jennifer Lee,Sung-Hwan Park,Ji Hyeon Ju,David Douglass Brand
PLOS ONE. 2017; 12(11): e0188698
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177 Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain
Min Kyoung Kim,Hyun Kang,Chong Wha Baek,Yong Hun Jung,Young Cheol Woo,Geun Joo Choi,Hwa Yong Shin,Kyung Soo Kim
Journal of Ginseng Research. 2017;
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178 Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia
Juan G. Zarruk,Andrew D. Greenhalgh,Samuel David
Experimental Neurology. 2017;
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179 Mesenchymal stem cell detachment with trace trypsin is superior to EDTA for in vitro chemotaxis and adhesion assays
David Fong,Nicholas Duceppe,Caroline D. Hoemann
Biochemical and Biophysical Research Communications. 2017;
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180 Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the s 1 receptor
Tangui Maurice,Manon Strehaiano,Fanny Duhr,Nathalie Chevallier
Behavioural Brain Research. 2017;
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181 Role of the plasma cascade systems in ischemia/reperfusion injury of bone
Shengye Zhang,Carlos Wotzkow,Anjan K. Bongoni,Jane Shaw-Boden,Mark Siegrist,Adriano Taddeo,Fabian Blank,Willy Hofstetter,Robert Rieben
Bone. 2017;
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182 Muscarinic acetylcholine receptor-mediated tight junction opening is involved in epiphora in late phase of submandibular gland transplantation
Ning-Yan Yang,Chong Ding,Jing Li,Yan Zhang,Ruo-Lan Xiang,Li-Ling Wu,Guang-Yan Yu,Xin Cong
Journal of Molecular Histology. 2017;
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183 Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress
Nino Goguadze,Elene Zhuravliova,Didier Morin,Davit Mikeladze,Tangui Maurice
Neurotoxicity Research. 2017;
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184 Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?
Paul A. Lapchak,Victor V. Uteshev
Translational Stroke Research. 2017;
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185 Translational Stroke Research Guideline Projections: The 20/20 Standards
Paul A. Lapchak,John H. Zhang
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186 Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors
Michelangelo Auteri,Maria Grazia Zizzo,Antonella Amato,Rosa Serio
Journal of Physiology and Biochemistry. 2017;
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187 A primer on systematic reviews in toxicology
Sebastian Hoffmann,Rob B. M. de Vries,Martin L. Stephens,Nancy B. Beck,Hubert A. A. M. Dirven,John R. Fowle,Julie E. Goodman,Thomas Hartung,Ian Kimber,Manoj M. Lalu,Kristina Thayer,Paul Whaley,Daniele Wikoff,Katya Tsaioun
Archives of Toxicology. 2017; 91(7): 2551
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188 Postmarketing withdrawal of human medicinal products because of adverse reactions in animals: a systematic review and analysis
Igho J. Onakpoya,Carl J. Heneghan,Jeffrey K. Aronson
Pharmacoepidemiology and Drug Safety. 2017;
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189 Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma
Elizabeth R. Tucker,Jennifer R. Tall,Laura S. Danielson,Sharon Gowan,Yann Jamin,Simon P. Robinson,Udai Banerji,Louis Chesler
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190 Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review
Meghan M. Moran,Brittany M. Wilson,Ryan D. Ross,Amarjit S. Virdi,Dale Rick Sumner
Journal of Orthopaedic Research. 2017;
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191 Taurine, caffeine, and energy drinks: Reviewing the risks to the adolescent brain
Christine Perdan Curran,Cecile A. Marczinski
Birth Defects Research. 2017; 109(20): 1640
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192 Animal Models in Translational Research: Rosetta Stone or Stumbling Block?
Jessica A. Bolker
BioEssays. 2017; : 1700089
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193 Influence of involuntary cigarette smoke inhalation on osseointegration: a systematic review and meta-analysis of preclinical studies
F. Javed,S.V. Kellesarian,T. Abduljabbar,A.T. Abduljabbar,Z. Akram,F. Vohra,I. Rahman,G.E. Romanos
International Journal of Oral and Maxillofacial Surgery. 2017;
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194 Evaluation of mandibular bone after dental extraction in rats treated with antiresorptive drugs
Victor Lousan Do Nascimento Poubel,Diogo Lenzi Capella,Adair Roberto Soares Santos,Márcio Correa,Letícia Ruhland Correa,Elena Riet Correa Rivero
Journal of Oral and Maxillofacial Surgery. 2017;
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195 AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids
Tanya S. King-Himmelreich,Christine V. Möser,Miriam C. Wolters,Julia Schmetzer,Yannik Schreiber,Nerea Ferreirós,Otto Q. Russe,Gerd Geisslinger,Ellen Niederberger
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196 227 th ENMC international workshop: finalizing a plan to guarantee quality in translational research for neuromuscular diseases
Raffaella Willmann,Filippo Buccella,Annamaria De Luca,Miranda D. Grounds
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197 Aminoguanidine alleviated MMA-induced impairment of cognitive ability in rats by downregulating oxidative stress and inflammatory reaction
Qiliang Li,Wenqi Song,Ze Tian,Peichang Wang
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198 sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain
Dan Kaufmann,Peter J. West,Misty D. Smith,Boris Yagen,Meir Bialer,Marshall Devor,H. Steve White,K.C. Brennan
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199 Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice
Genevieve A. Bell,Debra Ann Fadool
Physiology & Behavior. 2017;
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200 Ein Instrument zur Erstellung von Leitlinienberichten: das RIGHT-Statement
Yaolong Chen,Kehu Yang,Ana Marušic,Amir Qaseem,Joerg J. Meerpohl,Signe Flottorp,Elie A. Akl,Holger J. Schünemann,Edwin S.Y. Chan,Yngve Falck-Ytter,Faruque Ahmed,Sarah Barber,Chiehfeng Chen,Mingming Zhang,Bin Xu,Jinhui Tian,Fujian Song,Hongcai Shang,Kun Tang,Qi Wang,Susan L. Norris,Valérie C. Labonté,Ralph Möhler,Ina Kopp,Monika Nothacker,Joerg J. Meerpohl
Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen. 2017;
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201 Acidotoxicity via Asic1a Mediates Cell Death during Oxygen Glucose Deprivation and Abolishes Excitotoxicity
Saurav Bhowmick,Jeanette T. Moore,Daniel L. Kirschner,Mary C. Curry,Emily G. Westbrook,Brian T. Rasley,Kelly L. Drew
ACS Chemical Neuroscience. 2017;
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202 Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs–CAIs) for the Treatment of Rheumatoid Arthritis
Silvia Bua,Lorenzo Di Cesare Mannelli,Daniela Vullo,Carla Ghelardini,Gianluca Bartolucci,Andrea Scozzafava,Claudiu T. Supuran,Fabrizio Carta
Journal of Medicinal Chemistry. 2017;
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203 Guided bone regeneration with particulate vs. block xenogenic bone substitutes: a pilot cone beam computed tomographic investigation
Goran I. Benic,Daniel S. Thoma,Ronald E. Jung,Ignacio M. Sanz,Silvan Unger,Antonio Cantalapiedra,Christoph H.F. Hämmerle
Clinical Oral Implants Research. 2017;
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204 Effect of microthreads on coronal bone healing of narrow-diameter implants with reverse-tapered design in beagle dogs
Yun-Young Chang,Su-Hwan Kim,Keun-Oh Park,Jeong-Ho Yun
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205 Primary ridge augmentation with collagenated xenogenic block bone substitute in combination with collagen membrane and rhBMP-2: a pilot histological investigation
Goran I. Benic,Myung-Jae Joo,So-Ra Yoon,Jae-Kook Cha,Ui-Won Jung
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206 Guided bone regeneration at zirconia and titanium dental implants: a pilot histological investigation
Goran I. Benic,Daniel S. Thoma,Ignacio Sanz-Martin,Fernando Munoz,Christoph H.F. Hämmerle,Antonio Cantalapiedra,Jens Fischer,Ronald E. Jung
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207 Bone response to functionally loaded, two-piece zirconia implants: A preclinical histometric study
Simone F. M. Janner,Michael Gahlert,Dieter D. Bosshardt,Stefan Roehling,Stefan Milz,Frank Higginbottom,Daniel Buser,David L. Cochran
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208 Primidone inhibits TRPM3 and attenuates thermal nociception in vivo
Ute Krügel,Isabelle Straub,Holger Beckmann,Michael Schaefer
PAIN. 2017; 158(5): 856
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209 Effect of local zoledronate delivery on osseointegration: a systematic review of preclinical studies
Sergio Varela Kellesarian,Shatha Subhi ALHarthi,Munerah Saleh Binshabaib,Fawad Javed
Acta Odontologica Scandinavica. 2017; : 1
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210 Assessing recent and remote associative olfactory memory in rats using the social transmission of food preference paradigm
Benjamin Bessières,Olivier Nicole,Bruno Bontempi
Nature Protocols. 2017; 12(7): 1415
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211 Acupuncture for behavioral changes of experimental depressive disorder: a systematic review and meta-analysis
Ren-zhong Kou,Hong Chen,Mei-ling Yu,Tian-cheng Xu,Shu-ping Fu,Sheng-feng Lu
Scientific Reports. 2017; 7(1)
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212 eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology
Barbara Bettegazzi,Serena Bellani,Paolo Roncon,Fabrizia Claudia Guarnieri,Alice Bertero,Franca Codazzi,Flavia Valtorta,Michele Simonato,Fabio Grohovaz,Daniele Zacchetti
Scientific Reports. 2017; 7(1)
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213 Inhibition of a9a10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain
Haylie K. Romero,Sean B. Christensen,Lorenzo Di Cesare Mannelli,Joanna Gajewiak,Renuka Ramachandra,Keith S. Elmslie,Douglas E. Vetter,Carla Ghelardini,Shawn P. Iadonato,Jose L. Mercado,Baldomera M. Olivera,J. Michael McIntosh
Proceedings of the National Academy of Sciences. 2017; : 201621433
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214 Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo
I. Posadas,L. Romero-Castillo,N. El Brahmi,D. Manzanares,S. Mignani,J.-P. Majoral,V. Ceña
Proceedings of the National Academy of Sciences. 2017; 114(37): E7660
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215 Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI
Rafal Panek, Liam Welsh, Lauren C.J. Baker, Maria A. Schmidt, Kee H. Wong, Angela M. Riddell, Dow-Mu Koh, Alex Dunlop, Dualta Mcquaid, James A. d'Arcy, Shreerang A. Bhide, Kevin J. Harrington, Christopher M. Nutting, Georgina Hopkinson, Cheryl Richardson, Carol Box, Suzanne A. Eccles, Martin O. Leach, Simon P. Robinson, Kate L. Newbold
Clinical Cancer Research. 2017; 23(15): 4233
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216 Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease
Masaki Fukui,Yoko Ogawa,Shin Mukai,Mizuka Kamoi,Teru Asato,Yutaka Kawakami,Kazuo Tsubota
Journal of Ophthalmology. 2017; 2017: 1
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217 Ginsenoside Rb1 for Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms
Qun Zheng,Xiao-Yi Bao,Peng-Chong Zhu,Qiang Tong,Guo-Qing Zheng,Yan Wang
Oxidative Medicine and Cellular Longevity. 2017; 2017: 1
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218 XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough
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American Journal of Respiratory and Critical Care Medicine. 2017; 196(10): 1255
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219 Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress
Giovanni Vitale,Monica Filaferro,Maria Vittoria Micioni Di Bonaventura,Valentina Ruggieri,Carlo Cifani,Remo Guerrini,Michele Simonato,Silvia Zucchini
Journal of Psychopharmacology. 2017; 31(6): 691
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220 Imaging of brain oxygenation with magnetic resonance imaging: A validation with positron emission tomography in the healthy and tumoural brain
Samuel Valable,Aurélien Corroyer-Dulmont,Ararat Chakhoyan,Lucile Durand,Jérôme Toutain,Didier Divoux,Louisa Barré,Eric T MacKenzie,Edwige Petit,Myriam Bernaudin,Omar Touzani,Emmanuel L Barbier
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221 Angiotensin II type II receptors and colonic dysmotility in 2,4-dinitrofluorobenzenesulfonic acid-induced colitis in rats
M. G. Zizzo,M. Auteri,A. Amato,G. Caldara,D. Nuzzo,M. Di Carlo,R. Serio
Neurogastroenterology & Motility. 2017; : e13019
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222 Susceptibility of different mouse strains to peri-implantitis
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223 Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms
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BMC Cancer. 2017; 17(1)
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224 Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa
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Journal of Neuroinflammation. 2017; 14(1)
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225 Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™)
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Parasites & Vectors. 2017; 10(1)
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226 The next step in translational research: lessons learned from the first preclinical randomized controlled trial
Gemma Llovera,Arthur Liesz
Journal of Neurochemistry. 2016; : n/a
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227 Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögren’s Syndrome
L.W. Zhang,X. Cong,Y. Zhang,T. Wei,Y.C. Su,A.C.A. Serrão,A.R.T. Brito,G.Y. Yu,H. Hua,L.L. Wu
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228 Inhalation anesthesia of rats: influence of the fraction of inspired oxygen on limb ischemia/reperfusion injury
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229 sec-Butylpropylacetamide (SPD) has antimigraine properties
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230 Fc-saxatilin, a snake venom disintegrin, suppresses hypoxia-induced vascular leakage by regulating endothelial occludin expression
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231 Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies
Maria G. Belvisi,Mark A. Birrell,Saifudin Khalid,Michael A. Wortley,Rachel Dockry,Julie Coote,Kimberley Holt,Eric Dubuis,Angela Kelsall,Sarah A. Maher,Sara Bonvini,Ashley Woodcock,Jaclyn A. Smith
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232 Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors
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233 Magnetic study on biodistribution and biodegradation of oral magnetic nanostructures in the rat gastrointestinal tract
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234 Whatæs a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives
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235 Assessment of the Cancer Risk of the Fat-Grafted Breast in a Murine Model
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[Pubmed] | [DOI]
236 Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential
Jennifer Y. Xie,Lindsey A. Chew,Xiaofang Yang,Yuying Wang,Chaoling Qu,Yue Wang,Lauren M. Federici,Stephanie D. Fitz,Matthew S. Ripsch,Michael R. Due,Aubin Moutal,May Khanna,Fletcher A. White,Todd W. Vanderah,Philip L. Johnson,Frank Porreca,Rajesh Khanna
PAIN. 2016; 157(9): 2124
[Pubmed] | [DOI]
237 Effects of the neutrophil elastase inhibitor EL-17 in rat adjuvant-induced arthritis
Lorenzo Di Cesare Mannelli,Laura Micheli,Lorenzo Cinci,Mario Maresca,Claudia Vergelli,Alessandra Pacini,Mark T. Quinn,Maria Paola Giovannoni,Carla Ghelardini
Rheumatology. 2016; : kew055
[Pubmed] | [DOI]
238 Histological assessment of hard and soft tissues surrounding a novel ceramic implant: a pilot study in the minipig
Antonio Liñares,Leticia Grize,Fernando Muñoz,Benjamin Evans Pippenger,Michel Dard,Olivier Domken,Juan Blanco-Carrión
Journal of Clinical Periodontology. 2016; 43(6): 538
[Pubmed] | [DOI]
239 Influence of platelet-derived growth factor on osseous remodeling properties of a variable-thread tapered dental implant in vivo
Peer W. Kämmerer,Eik Schiegnitz,Victor Palarie,Michael Dau,Bernhard Frerich,Bilal Al-Nawas
Clinical Oral Implants Research. 2016; : n/a
[Pubmed] | [DOI]
240 Pectin nanocoating of titanium implant surfaces - an experimental study in rabbits
Katarzyna Gurzawska,Kai Dirscherl,Bodil Jørgensen,Tord Berglundh,Niklas Rye Jørgensen,Klaus Gotfredsen
Clinical Oral Implants Research. 2016; : n/a
[Pubmed] | [DOI]
241 Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice
AL Gavito,R Cabello,J Suarez,A Serrano,F J Pavón,M Vida,M Romero,V Pardo,D Bautista,S Arrabal,J Decara,AL Cuesta,A M Valverde,F Rodríguez de Fonseca,E Baixeras
British Journal of Pharmacology. 2016; 173(6): 1070
[Pubmed] | [DOI]
242 BN-9, a chimeric peptide with mixed opioid and neuropeptide FF receptor agonistic properties, produces nontolerance-forming antinociception in mice
Ning Li,Zheng-lan Han,Zi-long Wang,Yan-hong Xing,Yu-long Sun,Xu-hui Li,Jing-jing Song,Ting Zhang,Run Zhang,Meng-na Zhang,Biao Xu,Quan Fang,Rui Wang
British Journal of Pharmacology. 2016; 173(11): 1864
[Pubmed] | [DOI]
243 Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood
Javier Calleja-Conde,Victor Echeverry-Alzate,Elena Giné,Kora-Mareen Bühler,Roser Nadal,Rafael Maldonado,Fernando Rodríguez de Fonseca,Antoni Gual,Jose Antonio López-Moreno
British Journal of Pharmacology. 2016;
[Pubmed] | [DOI]
244 Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations
Alessio Nocentini,Marta Ferraroni,Fabrizio Carta,Mariangela Ceruso,Paola Gratteri,Cecilia Lanzi,Emanuela Masini,Claudiu T. Supuran
Journal of Medicinal Chemistry. 2016; 59(23): 10692
[Pubmed] | [DOI]
245 Accounting for reciprocal host–microbiome interactions in experimental science
Thaddeus S. Stappenbeck,Herbert W. Virgin
Nature. 2016; 534(7606): 191
[Pubmed] | [DOI]
246 Orthodontics treatments for managing obstructive sleep apnea syndrome in children: A systematic review and meta-analysis
Nelly T. Huynh,Eve Desplats,Fernanda R. Almeida
Sleep Medicine Reviews. 2016; 25: 84
[Pubmed] | [DOI]
247 Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors
Jing Yang,Hui Juan Jin,Elisabeth Mocaër,Laure Seguin,Hua Zhao,Benjamin Rusak
Life Sciences. 2016; 155: 147
[Pubmed] | [DOI]
248 Effects of low-level laser therapy on bone healing of critical-size defects treated with bovine bone graft
Alvaro Francisco Bosco,Paula Lazilha Faleiros,Luana Rodrigues Carmona,Valdir Gouveia Garcia,Letícia Helena Theodoro,Nathália Januario de Araujo,Maria José Hitomi Nagata,Juliano Milanezi de Almeida
Journal of Photochemistry and Photobiology B: Biology. 2016; 163: 303
[Pubmed] | [DOI]
249 A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis
Sara Consalvi,Giovanna Poce,Rino Ragno,Manuela Sabatino,Concettina La Motta,Stefania Sartini,Vincenzo Calderone,Alma Martelli,Carla Ghelardini,Lorenzo Di Cesare Mannelli,Mariangela Biava
ChemMedChem. 2016;
[Pubmed] | [DOI]
250 The Versatile 2-Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5-HT1A Receptor
Fabio Del Bello,Antonio Cilia,Antonio Carrieri,Domenico Claudio Fasano,Carla Ghelardini,Lorenzo Di Cesare Mannelli,Laura Micheli,Carlo Santini,Eleonora Diamanti,Mario Giannella,Gianfabio Giorgioni,Valerio Mammoli,Corinne Dalila Paoletti,Riccardo Petrelli,Alessandro Piergentili,Wilma Quaglia,Maria Pigini
ChemMedChem. 2016; 11(20): 2287
[Pubmed] | [DOI]
251 Repression of telomere-associated genes by microglia activation in neuropsychiatric disease
Golo Kronenberg,Ria Uhlemann,Johanna Schöner,Stephanie Wegner,Valérie Boujon,Nikolas Deigendesch,Matthias Endres,Karen Gertz
European Archives of Psychiatry and Clinical Neuroscience. 2016;
[Pubmed] | [DOI]
252 Local injection of granulocyte-colony stimulating factor accelerates wound healing in a rat excisional wound model
Guang-Yin Shen,In-Hwa Park,Yi-Sun Song,Hyun-Woo Joo,Yonggu Lee,Jeong-Hun Shin,Kyung-Soo Kim,Hyuck Kim
Tissue Engineering and Regenerative Medicine. 2016; 13(3): 297
[Pubmed] | [DOI]
253 Toward more predictive genetic mouse models of Alzheimeræs disease
Kristen D. Onos,Stacey J. Sukoff Rizzo,Gareth R. Howell,Michael Sasner
Brain Research Bulletin. 2016; 122: 1
[Pubmed] | [DOI]
254 Preclinical platform of retinoblastoma xenografts recapitulating human disease and molecular markers of dissemination
Guillem Pascual-Pasto,Nagore G. Olaciregui,Monica Vila-Ubach,Sonia Paco,Carles Monterrubio,Eva Rodriguez,Ursula Winter,Mireia Batalla-Vilacis,Jaume Catala,Hector Salvador,Andreu Parareda,Paula Schaiquevich,Mariona Suñol,Jaume Mora,Cinzia Lavarino,Carmen de Torres,Guillermo L. Chantada,Angel M. Carcaboso
Cancer Letters. 2016; 380(1): 10
[Pubmed] | [DOI]
255 Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide
L.M.D. Gonçalves,F. Maestrelli,L. Di Cesare Manelli,C. Ghelardini,A.J. Almeida,P. Mura
European Journal of Pharmaceutics and Biopharmaceutics. 2016; 102: 41
[Pubmed] | [DOI]
256 The a9a10 nicotinic receptor antagonist a-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment
Alessandra Pacini,Laura Micheli,Mario Maresca,Jacopo Juno Valerio Branca,J. Michael McIntosh,Carla Ghelardini,Lorenzo Di Cesare Mannelli
Experimental Neurology. 2016; 282: 37
[Pubmed] | [DOI]
257 Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy
Lorenzo Di Cesare Mannelli,Matteo Zanardelli,Ida Landini,Alessandra Pacini,Carla Ghelardini,Enrico Mini,Andrea Bencini,Barbara Valtancoli,Paola Failli
Free Radical Biology and Medicine. 2016; 93: 67
[Pubmed] | [DOI]
258 Bone computed tomography mineral content evaluation in chickens: effects of substances in homeopathic concentration
Sergio Canello,Gabriele Gasparini,Patrizio Luisetto,Alessandro Di Cerbo,Fabio Pomerri
Homeopathy. 2016; 105(1): 92
[Pubmed] | [DOI]
259 Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review
Gbeminiyi O. Samuel,Sebastian Hoffmann,Robert A. Wright,Manoj Mathew Lalu,Grace Patlewicz,Richard A. Becker,George L. DeGeorge,Dean Fergusson,Thomas Hartung,R. Jeffrey Lewis,Martin L. Stephens
Environment International. 2016;
[Pubmed] | [DOI]
260 Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s Disease
Chien-Wei Feng,Han-Chun Hung,Shi-Ying Huang,Chun-Hong Chen,Yun-Ru Chen,Chun-Yu Chen,San-Nan Yang,Hui-Min Wang,Ping-Jyun Sung,Jyh-Horng Sheu,Kuan-Hao Tsui,Wu-Fu Chen,Zhi-Hong Wen
Marine Drugs. 2016; 14(10): 187
[Pubmed] | [DOI]
261 Carbonic anhydrase inhibition for the management of cerebral ischemia:in vivoevaluation of sulfonamide and coumarin inhibitors
Lorenzo Di Cesare Mannelli,Laura Micheli,Fabrizio Carta,Andrea Cozzi,Carla Ghelardini,Claudiu T. Supuran
Journal of Enzyme Inhibition and Medicinal Chemistry. 2015; : 1
[Pubmed] | [DOI]
262 Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity
Lorenzo Di Cesare Mannelli,Alessandra Pacini,Francesca Corti,Serena Boccella,Livio Luongo,Emanuela Esposito,Salvatore Cuzzocrea,Sabatino Maione,Antonio Calignano,Carla Ghelardini,Theodore John Price
PLOS ONE. 2015; 10(6): e0128080
[Pubmed] | [DOI]
263 Brain-Derived Neurotrophic Factor and Antidepressive Effect of Electroconvulsive Therapy: Systematic Review and Meta-Analyses of the Preclinical and Clinical Literature
M. Polyakova,M. L. Schroeter,B. M. Elzinga,S. Holiga,P. Schoenknecht,E. R. de Kloet,M. L. Molendijk,Lin Lu
PLOS ONE. 2015; 10(11): e0141564
[Pubmed] | [DOI]
264 Minimizing chemotherapy-induced peripheral neuropathy: preclinical and clinical development of new perspectives
Laura Poupon,Nicolas Kerckhove,Julie Vein,Sylvain Lamoine,Nicolas Authier,Jérôme Busserolles,David Balayssac
Expert Opinion on Drug Safety. 2015; 14(8): 1269
[Pubmed] | [DOI]
265 Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats
Juliano De Almeida,Edilson Ervolino,Luiz Henrique Bonfietti,Vivian Cristina Noronha Novaes,Letícia Helena Theodoro,Leandro Araujo Fernandes,Thiago Marchi Martins,Paula Lazilha Faleiros,Valdir Gouveia Garcia
Journal of Periodontology. 2015; 86(10): 1166
[Pubmed] | [DOI]
266 A meta-analysis of efficacy in pre-clinical human stem cell therapies for traumatic brain injury
Janessa Chang,Michael Phelan,Brian J. Cummings
Experimental Neurology. 2015; 273: 225
[Pubmed] | [DOI]
267 Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats
Laura Micheli,Lorenzo Di Cesare Mannelli,Remo Guerrini,Claudio Trapella,Matteo Zanardelli,Roberto Ciccocioppo,Anna Rizzi,Carla Ghelardini,Girolamo Calò
European Journal of Pharmacology. 2015; 754: 73
[Pubmed] | [DOI]
268 In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine
Annunziatina Laurino,Gaetano De Siena,Alessandro Saba,Grazia Chiellini,Elisa Landucci,Riccardo Zucchi,Laura Raimondi
European Journal of Pharmacology. 2015; 761: 130
[Pubmed] | [DOI]
269 Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity
Laura Micheli,Lorenzo Di Cesare Mannelli,Anna Rizzi,Remo Guerrini,Claudio Trapella,Girolamo Calò,Carla Ghelardini
European Journal of Pharmacology. 2015; 766: 155
[Pubmed] | [DOI]
270 Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review
F. Faot,M. Chatterjee,G.V. de Camargos,Joke Duyck,K. Vandamme
Bone Reports. 2015; 2: 14
[Pubmed] | [DOI]
271 Early postnatal handling and environmental enrichment improve the behavioral responses of 17-month-old 3xTg-AD and non-transgenic mice in the Forced Swim Test in a gender-dependent manner
Virginia Torres-Lista,Lydia Giménez-Llort
Behavioural Processes. 2015; 120: 120
[Pubmed] | [DOI]
272 A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects
Fabrizio Carta,Lorenzo Di Cesare Mannelli,Melissa Pinard,Carla Ghelardini,Andrea Scozzafava,Robert McKenna,Claudiu T. Supuran
Bioorganic & Medicinal Chemistry. 2015; 23(8): 1828
[Pubmed] | [DOI]
273 Quel modèle murin d’infarctus cérébral choisir pour permettre une recherche translationnelle plus efficace ?
Clément Gakuba,Morgane Louessard,Marina Rubio,Hélène Party,Antonin Doyere,Marine Lerouvillois,Suzanne Goursaud,Jean-Luc Hanouz,Emmanuel Touzé,Véronique Agin,Denis Vivien,Maxime Gauberti
Anesthésie & Réanimation. 2015; 1: A46
[Pubmed] | [DOI]
274 Increased a1-adrenoreceptor activity is required to sustain blood pressure in female rats under food restriction
Aline Arlindo de Souza,Rodrigo Cunha de Menezes,Aline Rezende Abreu,Glaucy Rodrigues Araujo,Daniela Caldeira Costa,Deoclecio Alves Chianca
Life Sciences. 2015; 128: 55
[Pubmed] | [DOI]
275 A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam
Lorenzo Di Cesare Mannelli,Mario Maresca,Carlo Farina,Michael W. Scherz,Carla Ghelardini
NeuroToxicology. 2015; 50: 101
[Pubmed] | [DOI]
276 Tail-flick test response in 3×Tg-AD mice at early and advanced stages of disease
Raquel Baeta-Corral,Ruti Defrin,Chagi G. Pick,Lydia Giménez-Llort
Neuroscience Letters. 2015; 600: 158
[Pubmed] | [DOI]
277 Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1
Lorenzo Di Cesare Mannelli,Manuela Marcoli,Laura Micheli,Matteo Zanardelli,Guido Maura,Carla Ghelardini,Chiara Cervetto
Neuropharmacology. 2015; 97: 133
[Pubmed] | [DOI]
278 Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia
Craig M McKittrick,Catherine E Lawrence,Hilary V O Carswell
Journal of Cerebral Blood Flow & Metabolism. 2015; 35(4): 638
[Pubmed] | [DOI]
279 Widespread pain reliever profile of a flower extract of Tanacetum parthenium
Lorenzo Di-Cesare Mannelli,Barbara Tenci,Matteo Zanardelli,Anna Maidecchi,Andrea Lugli,Luisa Mattoli,Carla Ghelardini
Phytomedicine. 2015; 22(7-8): 752
[Pubmed] | [DOI]
280 Research synthesis in veterinary science: Narrative reviews, systematic reviews and meta-analysis
Annette OæConnor,Jan Sargeant
The Veterinary Journal. 2015; 206(3): 261
[Pubmed] | [DOI]
281 A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury
Ting-Ting Li,Man-Li Fan,Shi-Xiang Hou,Xiao-Yi Li,Devin M Barry,Hui Jin,Sheng-Yong Luo,Feng Kong,Lit-Fui Lau,Xiang-Rong Dai,Guo-Hui Zhang,Lan-Lan Zhou
British Journal of Pharmacology. 2015; 172(15): 3904
[Pubmed] | [DOI]
282 Mechanical competence of ovariectomy-induced compromised bone after single or combined treatment with high-frequency loading and bisphosphonates
Maxime Camargos G. V.,Maxime Bhattacharya P.,Maxime van Lenthe G. H.,Maxime Del Bel Cury A. A.,Maxime Naert I.,Maxime Duyck J.,Maxime Vandamme K.
Scientific Reports. 2015; 5: 10795
[Pubmed] | [DOI]
283 Uric Acid Produces an Inflammatory Response through Activation of NF-?B in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders
Wenjie Lu,Youzhi Xu,Xiaoni Shao,Fabao Gao,Yan Li,Jing Hu,Zeping Zuo,Xue Shao,Liangxue Zhou,Yinglan Zhao,Xiaobo Cen
Scientific Reports. 2015; 5: 12144
[Pubmed] | [DOI]
284 The Metabolic Effects of Consumption of Yellow Cassava (Manihot esculenta Crantz) on Some Biochemical Parameters in Experimental Rats
Nelson Udeme,Polycarp Okafor,Chinedum Eleazu
International Journal of Toxicology. 2015; 34(6): 559
[Pubmed] | [DOI]
285 Pyruvate stabilizes electrocardiographic and hemodynamic function in pigs recovering from cardiac arrest
Brandon H Cherry,Anh Q Nguyen,Roger A Hollrah,Arthur G Williams,Besim Hoxha,Albert H Olivencia-Yurvati,Robert T Mallet
Experimental Biology and Medicine. 2015; 240(12): 1774
[Pubmed] | [DOI]
286 Periodontal ligament-derived cells for periodontal regeneration in animal models: a systematic review
R. Bright,K. Hynes,S. Gronthos,P. M. Bartold
Journal of Periodontal Research. 2015; 50(2): 160
[Pubmed] | [DOI]
287 Peri-implant soft tissue analyses comparing Ti and ZrO2abutments: an animal study on beagle dogs
Juan Blanco,Leticia Caneiro,Antonio Liñares,Pilar Batalla,Fernando Muñoz,Isabel Ramos
Clinical Oral Implants Research. 2015; : n/a
[Pubmed] | [DOI]
288 Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis
Claire A. Sand,Anna Starr,Catherine D. E. Wilder,Olena Rudyk,Domenico Spina,Christoph Thiemermann,David F. Treacher,Manasi Nandi
Journal of Applied Physiology. 2015; 118(3): 344
[Pubmed] | [DOI]
289 Reduced ß-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells
Claudia Späni,Tobias Suter,Rebecca Derungs,Maria Teresa Ferretti,Tobias Welt,Fabian Wirth,Christoph Gericke,Roger M. Nitsch,Luka Kulic
Acta Neuropathologica Communications. 2015; 3(1)
[Pubmed] | [DOI]
290 Unmanipulated native fat exposed to high-energy diet, but not autologous grafted fat by itself, may lead to overexpression of Ki67 and PAI-1
Francisco Claro,Joseane Morari,Luciana R Moreira,Luís O Z Sarian,Glauce A Pinto,Licio A Velloso,Aarão M Pinto-Neto
SpringerPlus. 2015; 4(1)
[Pubmed] | [DOI]
291 Electrical impedance tomography (EIT) for quantification of pulmonary edema in acute lung injury
Constantin J. C. Trepte,Charles R. Phillips,Josep Solà,Andy Adler,Sebastian A. Haas,Michael Rapin,Stephan H. Böhm,Daniel A. Reuter
Critical Care. 2015; 20(1)
[Pubmed] | [DOI]
292 Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy
Ilya Chumakov,Aude Milet,Nathalie Cholet,Gwenaël Primas,Aurélie Boucard,Yannick Pereira,Esther Graudens,Jonas Mandel,Julien Laffaire,Julie Foucquier,Fabrice Glibert,Viviane Bertrand,Klaus-Armin Nave,Michael W Sereda,Emmanuel Vial,Mickaël Guedj,Rodolphe Hajj,Serguei Nabirotchkin,Daniel Cohen
Orphanet Journal of Rare Diseases. 2014; 9(1): 201
[Pubmed] | [DOI]
293 A universal protocol to generate consensus level genome sequences for foot-and-mouth disease virus and other positive-sense polyadenylated RNA viruses using the Illumina MiSeq
Grace Logan, Graham L Freimanis, David J King, Begoña Valdazo-González, Katarzyna Bachanek-Bankowska, Nicholas D Sanderson, Nick J Knowles, Donald P King, Eleanor M Cottam
BMC Genomics. 2014; 15(1)
[Pubmed] | [DOI]
294 Ligature-induced peri-implantitis in mice
F. Q. Pirih,S. Hiyari,A. D. V. Barroso,A. C. A. Jorge,J. Perussolo,E. Atti,S. Tetradis,P. M. Camargo
Journal of Periodontal Research. 2014; : n/a
[Pubmed] | [DOI]
295 Electrophysiological, behavioral and histological characterization of paclitaxel, cisplatin, vincristine and bortezomib-induced neuropathy in C57Bl/6 mice
Wolfgang Boehmerle,Petra Huehnchen,Sarah Peruzzaro,Mustafa Balkaya,Matthias Endres
Scientific Reports. 2014; 4: 6370
[Pubmed] | [DOI]
296 Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic Neurodegeneration
Ayodeji A. Asuni,Bryony Gray,Joanne Bailey,Paul Skipp,V. Hugh Perry,Vincent OæConnor
Journal of Biological Chemistry. 2014; 289(7): 4532
[Pubmed] | [DOI]
297 Individualized Early Goal-Directed Therapy in Systemic Inflammation
Karin H. Wodack,Annika M. Poppe,Tomköetter Lena,Kai A. Bachmann,Cilly M. Strobel,Sarah Bonk,Jan Havel,Kai Heckel,Andreas Gocht,Bernd Saugel,Oliver Mann,Jakob R. Izbicki,Alwin E. Goetz,Constantin J. C. Trepte,Daniel A. Reuter
Critical Care Medicine. 2014; 42(12): e741
[Pubmed] | [DOI]
298 Influence of mechanical instruments on the biocompatibility of titanium dental implants surfaces: a systematic review
Anna Louropoulou,Dagmar E. Slot,Fridus Van der Weijden
Clinical Oral Implants Research. 2014; : n/a
[Pubmed] | [DOI]
299 Assessment of three approaches for regulatory decision making on pesticides with endocrine disrupting properties
P. Marx-Stoelting,L. Niemann,V. Ritz,B. Ulbrich,A. Gall,K.I. Hirsch-Ernst,R. Pfeil,R. Solecki
Regulatory Toxicology and Pharmacology. 2014;
[Pubmed] | [DOI]
300 Improving standards for reporting studies involving humans and experimental animals in the British Journal of Nutrition and in the Journal of Nutritional Science
Graham C. Burdge
British Journal of Nutrition. 2014; : 1
[Pubmed] | [DOI]
301 Improving standards for reporting studies involving humans and experimental animals in the British Journal of Nutrition and in the Journal of Nutritional Science
Graham C. Burdge
Journal of Nutritional Science. 2014; 3
[Pubmed] | [DOI]
302 Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP)
Myriam Heiman,Ruth Kulicke,Robert J Fenster,Paul Greengard,Nathaniel Heintz
Nature Protocols. 2014; 9(6): 1282
[Pubmed] | [DOI]
303 Rigor or Mortis: Best Practices for Preclinical Research in Neuroscience
Oswald Steward,Rita Balice-Gordon
Neuron. 2014; 84(3): 572
[Pubmed] | [DOI]
304 Bizarre behaviors and risk assessment in 3xTg-AD mice at early stages of the disease
R. Baeta-Corral,L. Giménez-Llort
Behavioural Brain Research. 2014; 258: 97
[Pubmed] | [DOI]
305 Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice
Wolfgang Boehmerle,Hanna Muenzfeld,Andreas Springer,Petra Huehnchen,Matthias Endres
Journal of Molecular Medicine. 2014;
[Pubmed] | [DOI]
306 Persistence of behaviours in the Forced Swim Test in 3xTg-AD mice at advanced stages of disease
Virginia Torres-Lista,Lydia Giménez-Llort
Behavioural Processes. 2014;
[Pubmed] | [DOI]
307 Pharmacological and methodological aspects of the separation-induced vocalization test in guinea pig pups; a systematic review and meta-analysis
Lucianne Groenink,P. Monika Verdouw,Brenda Bakker,Kimberley E. Wever
European Journal of Pharmacology. 2014;
[Pubmed] | [DOI]
308 The Need for Randomization in Animal Trials: An Overview of Systematic Reviews
Jennifer A. Hirst,Jeremy Howick,Jeffrey K. Aronson,Nia Roberts,Rafael Perera,Constantinos Koshiaris,Carl Heneghan,Brett Thombs
PLoS ONE. 2014; 9(6): e98856
[Pubmed] | [DOI]
309 The Conditioned Place Preference Test for Assessing Welfare Consequences and Potential Refinements in a Mouse Bladder Cancer Model
John V. Roughan,Claire A. Coulter,Paul A. Flecknell,Huw D. Thomas,Kenneth J. Sufka,Bradley Taylor
PLoS ONE. 2014; 9(8): e103362
[Pubmed] | [DOI]
310 Antiinflammatory Effect of Phytosterols in Experimental Murine Colitis Model: Prevention, Induction, Remission Study
Rita Aldini,Matteo Micucci,Monica Cevenini,Romana Fato,Christian Bergamini,Cristina Nanni,Massimiliano Cont,Cecilia Camborata,Silvia Spinozzi,Marco Montagnani,Giulia Roda,Antonia DæErrico-Grigioni,Francesca Rosini,Aldo Roda,Giuseppe Mazzella,Alberto Chiarini,Roberta Budriesi,Udai P. Singh
PLoS ONE. 2014; 9(9): e108112
[Pubmed] | [DOI]
311 Identification of hyperacute ischemic stroke with a more homogenous nature
Kyung Yi,Hong Lee,Sang-Rae Lee,Youngjeon Lee,Seung Lee,Chulhyun Lee,Sang-Hoon Cha
Translational Neuroscience. 2014; 5(2)
[Pubmed] | [DOI]
312 Systematic evaluation of medium-throughput mRNA abundance platforms
Stephenie D. Prokopec, John D. Watson, Daryl M. Waggott, Ashley B. Smith, Alexander H. Wu, Allan B. Okey, Raimo Pohjanvirta, Paul C. Boutros
RNA. 2013; 19(1): 51
[Pubmed] | [DOI]
313 Inhalation of carbon monoxide following resuscitation ameliorates hemorrhagic shock-induced lung injury
SUSUMU KAWANISHI,TORU TAKAHASHI,HIROSHI MORIMATSU,HIROKO SHIMIZU,EMIKO OMORI,KENJI SATO,MASAKI MATSUMI,SHIGERU MAEDA,ATSUNORI NAKAO,KIYOSHI MORITA
Molecular Medicine Reports. 2013; 7(1): 3
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314 The association of hydrogel and biphasic calcium phosphate in the treatment of dehiscence-type peri-implant defects: an experimental study in dogs
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