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Year : 2014  |  Volume : 5  |  Issue : 3  |  Page : 220-221  

New(s): Are these terms new(s)!?

Department of Pharmacology, Indira Gandhi Medical College and Research Institute, Kadhirkamam, Puducherry, India

Date of Web Publication5-Jul-2014

Correspondence Address:
G Sivagnanam
Department of Pharmacology, Indira Gandhi Medical College and Research Institute, Kadhirkamam - 605 009, Puducherry
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Source of Support: None, Conflict of Interest: None

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How to cite this article:
Sivagnanam G. New(s): Are these terms new(s)!?. J Pharmacol Pharmacother 2014;5:220-1

How to cite this URL:
Sivagnanam G. New(s): Are these terms new(s)!?. J Pharmacol Pharmacother [serial online] 2014 [cited 2022 Jan 23];5:220-1. Available from:

Therapeutic inertia

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Synthetic cannabimimetics are termed as "spice" drugs. The term 'Spiceophrenia' describes the acute psychosis triggered by synthetic cannabinoids, known on the street as "K2" or "spice." A systematic review on this subject can be viewed here. [1]


Study of microbiome (refers to the community of microorganism that live in or on the human body) composition and functional variations affecting drug action, fate, and toxicity. View these references for more details. [2],[3]


'Deprescribing' was first used a decade ago in Australia by Woodward to describe the cessation of medicines. [4] Although the evidence-base for deprescribing is limited due to paucity of robust studies, the weight of evidence shows that for most medicines, deprescribing is not harmful in the majority of frail, older people and may be beneficial. [5] For e.g. withdrawal of antipsychotics for challenging behavior in dementia has been shown to reduce mortality. [6]

Therapeutic inertia

The term 'Therapeutic inertia' first appeared in the MEDLINE-indexed literature in an article in July 2004. [7] It was later perhaps inadvertently, referenced as 'therapeutic inertia'- as the "failure of providers to begin new medications or increase dosages of existing medications when an abnormal clinical parameter is recorded." [8]

However the original authors to define "Clinical inertia' were Phillips et al. [9] They defined clinical inertia as, "failure of health care providers to initiate or intensify therapy when indicated" and "recognition of the problem, but failure to act".

   References Top

1.Papanti D, Schifano F, Botteon G, Bertossi F, Mannix J, Vidoni D, et al. "Spiceophrenia": A systematic overview of "spice"- related psychopathological issues and a case report. Hum Psychopharmacol 2013;28:379-89.  Back to cited text no. 1
2.Saad R, Rizkallah MR, Aziz RK. Gut Pharmacomicrobiomics: The tip of an iceberg of complex interactions between drugs and gut-associated microbes. Gut Pathog 2012;4:16.  Back to cited text no. 2
3.Elrakaiby M, Dutilh BE, Rizkallah MR, Boleij A, Cole JN, Aziz RK. Pharmacomicrobiomics: The Impact of Human Microbiome Variations on Systems Pharmacology and Personalized Therapeutics. OMICS 2014. Available from: [Last accessed on 2014 May 4].  Back to cited text no. 3
4.Woodward M. Deprescribing: Achieving better health outcomes for older people through reducing medication. J Pharm Pract Res 2003;33:323-28.  Back to cited text no. 4
5.Gnjidic D, Le Couteur DG, Kouladjian L, Hilmer SN. Deprescribing trials: Methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clin Geriatr Med 2012;28:237-53.  Back to cited text no. 5
6.Ballard C, Hanney ML, Theodoulou M, Douglas S, McShane R, Kossakowski K, et al. DART-AD investigators. The dementia antipsychotic withdrawal trial (DART-AD): Long-term follow-up of a randomised placebo-controlled trial. Lancet Neurol 2009;8:151-7.  Back to cited text no. 6
7.Andrade SE, Gurwitz JH, Field TS, Kelleher M, Majumdar SR, Reed G, et al. Hypertension management: The care gap between clinical guidelines and clinical practice. Am J Manag Care 2004;10:481-6.  Back to cited text no. 7
8.Okonofua EC, Simpson KN, Jesri A, Rehman SU, Durkalski VL, Egan BM. Therapeutic inertia is an impediment to achieving the Healthy People 2010 blood pressure control goals. Hypertension 2006;47:345-51.  Back to cited text no. 8
9.Phillips LS, Branch WT, Cook CB, Doyle JP, El-Kebbi IM, Gallina DL, et al. Clinical inertia. Ann Intern Med 2001;135:825-34.  Back to cited text no. 9


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