Journal of Pharmacology and Pharmacotherapeutics

MINI REVIEW
Year
: 2021  |  Volume : 12  |  Issue : 3  |  Page : 120--124

A mini review: Mucormycosis in coronavirus disease-19, host-iron assimilation, and probiotics as novel therapy


Ankit Bhardwaj1, Vandana Roy2, Indu Priyadarshini1 
1 Department of Pharmacology, ABVIMS and Dr. RML Hospital, New Delhi, India
2 Department of Pharmacology, MAMC and LNJP Hospital, New Delhi, India

Correspondence Address:
Dr. Ankit Bhardwaj
Department of Pharmacology, ABVIMS and Dr. RML Hospital, Baba Kharak Singh Marg, Near Gurudwara Bangla Sahib, Connaught Place, New Delhi - 110 001
India

Mucormycosis is an acute fungal infection with 90% of cases in the form of rhino-orbito-cerebellar. It is an aggressive and life-threatening fungal infection causing 50% mortality in people with coronavirus disease 2019 (COVID-19). In COVID-infected patients due to, diabetic ketoacidosis, epithelial damage, ciliary dysfunction, dysfunctional phagocytic mechanism, and immunosuppression, there is impaired chemotaxis and defective intracellular killing leads to fungal spores to invade, germinate and penetrate in surrounding tissues. The use of broad-spectrum antibiotics disrupts the normal microbiomes and increases the probability of growth of Rhizopus spp. Commercially available probiotics such as Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, and Saccharomyces when administered in adequate quantities form siderophores which induces iron stress in fungus and inhibits spore germination.


How to cite this article:
Bhardwaj A, Roy V, Priyadarshini I. A mini review: Mucormycosis in coronavirus disease-19, host-iron assimilation, and probiotics as novel therapy.J Pharmacol Pharmacother 2021;12:120-124


How to cite this URL:
Bhardwaj A, Roy V, Priyadarshini I. A mini review: Mucormycosis in coronavirus disease-19, host-iron assimilation, and probiotics as novel therapy. J Pharmacol Pharmacother [serial online] 2021 [cited 2022 Jan 16 ];12:120-124
Available from: http://www.jpharmacol.com/article.asp?issn=0976-500X;year=2021;volume=12;issue=3;spage=120;epage=124;aulast=Bhardwaj;type=0