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  Indian J Med Microbiol
 

Figure 1: Mechanism of iron uptake by Mucorales during mucormycosis.(A) Heme is likely to present as source of iron as disease is angioinvasive in nature. Fungus takes up heme intracellularly or strips ferric iron from heme by action of reductase-permease system. Ferric iron is obtained by action of heme oxygenase, if heme is transported intracellularly. (B) in patients with DKA, there is proton (H+)- mediated displacement of ferric iron (Fe3+) from transferrin (T) increase the availability of iron, transported intracellularly by reductase permease system. Deferasirox (D) chelates iron from transferrin directly resulting in formation of ferrioxamine (iron-deferasirox complex). Fungus then liberates ferrous iron ferrioxamine by reduction at cell surface. Iron is transported across the cell membrane by copper oxidase -iron permease (FTR1) complex

Figure 1: Mechanism of iron uptake by Mucorales during mucormycosis.(A) Heme is likely to present as source of iron as disease is angioinvasive in nature. Fungus takes up heme intracellularly or strips ferric iron from heme by action of reductase-permease system. Ferric iron is obtained by action of heme oxygenase, if heme is transported intracellularly. (B) in patients with DKA, there is proton (H+)- mediated displacement of ferric iron (Fe3+) from transferrin (T) increase the availability of iron, transported intracellularly by reductase permease system. Deferasirox (D) chelates iron from transferrin directly resulting in formation of ferrioxamine (iron-deferasirox complex). Fungus then liberates ferrous iron ferrioxamine by reduction at cell surface. Iron is transported across the cell membrane by copper oxidase -iron permease (FTR1) complex