Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRitlecitinib (RIT) is a novel kinase inhibitor with promising therapeutic applications in the treatment of autoimmune disease alopecia areata. Accurate quantification of RIT in biological matrices is essential for pharmacokinetic studies and drug development.ObjectivesThis study aims to develop and validate a sensitive…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: The most common condition that restricts movement is low back pain, which is particularly common in the most productive years of life. Sciatica syndrome accounts for 40% of patients’ severe lower back pain. Psychological strain places excessive strain on the spinal…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundMachine Learning-powered Internet of Medical Things (MLIoMT) is a burgeoning framework poised to transform healthcare, particularly in the timely identification of heart disease.PurposeThis article proposes an innovative MLIoMT structure aimed at leveraging machine learning (ML) algorithms for heart disease detection.MethodsThrough the integration…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundPlants are attractive sources of anti-cancer agents. However, there is limited data about the anti-cancer potential of Ethiopian medicinal plants traditionally used for the treatment of cancer.PurposeTo screen the cytotoxicity of 26 Ethiopian medicinal plants against breast cancer cells (MCF-7) and to…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAs traditional laboratory animal use faces ethical and logistical constraints, the chick ileum has been experimented with as an alternate tissue for bioassays, which is crucial for drug discovery and pharmacology education. However, the absence of uniform bioassay protocols for chick ileum…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundInsomnia is a significant public health problem that can affect up to 50% of older adults. Pharmacological treatments are commonly used such as benzodiazepines (BZD) and related Z-drug zopiclone.PurposeThe objective of this study was to investigate the use of zopiclone under real-life…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAlzheimer’s disease (AD) is a complex neurological disorder characterized by neuronal loss and progressive cognitive decline. The disease progression is influenced by both environmental and genetic factors. Recent research highlights the significant role of vitamin D in the pathological progression of AD.PurposeThis…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundLow back pain is a pervasive and often debilitating musculoskeletal condition that affects millions of people worldwide. Low back pain affects 619 million globally (10%) and may rise to 843 million by 2050. It causes 8% years lived with disability and 4.6%…