Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Purpose/BackgroundThis study aimed to isolate, purify, and characterize a novel bacteriocin produced byLactobacillus caseistrain GO3, isolated from goat milk. Bacteriocins are promising natural antimicrobial agents with potential applications in food …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundEpilepsy affects around 70 million people worldwide, with a higher prevalence in developing countries like Malaysia. Antiepileptic drugs (AEDs) such as carbamazepine, phenobarbitone, valproic acid, and phenytoin are essential for managing …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundUbrogepant is a first-generation gepant-class drug approved for the oral treatment of migraine.PurposeThis work aimed at developing an intranasal gel consisting of ubrogepant nanoparticles (NPs), with the aim of improving its therapeutic …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundPrescriptions are medication plans communicated between prescribers and pharmacists for patients. An ideal prescription must be rational, evidence-based, complete, and clear, and enhance the therapeutic outcome of the patient. Elderly patients …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background/PurposeDiabetes and cancer are common diseases, and epidemiologic evidence suggests that people with diabetes are at significantly higher risk for many forms of cancer. Both these diseases are among the highly complex, heterogeneous, and …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAutomatic lung segmentation is a crucial initial step in computer-aided lung computed tomography (CT) diagnosis. However, existing methods struggle to achieve accurate segmentation in the presence of dense abnormalities, limiting their clinical …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundVitamin D deficiency poses significant health risks globally, impacting bone health and immune function. In Saudi Arabia, where environmental and lifestyle factors limit sun exposure, vitamin D deficiency is especially prevalent. This study …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background/PurposeComplications associated with diabetes are predominantly influenced by the polyol pathway, in which aldose reductase 2 (ALR2) is instrumental in converting surplus glucose into sorbitol, resulting in oxidative stress and cellular injury. …Read Original Source