Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundNigella sativais the source of thymoquinone (TQ), an active phenolic compound with numerous pharmacological properties, including anti-tumor, anti-angiogenic, and antioxidant activities. Nevertheless, the mechanism by which TQ exerts its …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRepurposing of a hydroxylmethylglutaryl coenzyme A reductase inhibitor like simvastatin has gained significant interest in oncologic treatment owing to the pleiotropic effects. However, the role of simvastatin in inhibiting epithelial-…Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Competency-based medical education (CBME) marks a paradigm shift in medical training by prioritizing outcomes over time-based progression and focusing on clearly defined competencies aligned with societal needs. Faculty serve as critical agents of this …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRegional anaesthesia is widely preferred for upper limb surgeries, particularly those performed below the elbow; however, the limited duration of action of local anaesthetics remains a clinical challenge. The addition of adjuvants such as …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Polycystic ovary syndrome (PCOS) is a chronic endocrine disorder affecting women of reproductive age, with a prevalence of about 10%. Hyperandrogenism, anovulation, polycystic ovarian morphology, and related hormonal and metabolic abnormalities are its …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundPatients with acute promyelocytic leukemia (APML) undergoing induction therapy are severely immunocompromised and prone to opportunistic infections. Tuberculosis (TB), though less commonly considered, can complicate the clinical course, …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundMRSA and PRSP resistance has surged over 30 years, threatening clinical outcomes; China-developed cefathiamidine sodium, with enhanced pharmacokinetics, offers potent activity against these Gram-positive pathogens.PurposeThis study evaluates the …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundBuprofezin, a thiadiazine insecticide globally recognized as a molting inhibitor, is widely used for controlling whitefly and other insect pests.PurposeThis study investigated the impacts of sub-lethal buprofezin concentrations (0.15, 0.30, and …Read Original Source