Journal of Pharmacology and Pharmacotherapeutics
Online First
Review Article
https://doi.org/10.1177/0976500X241312726
Online First
Review Article
https://doi.org/10.1177/0976500X241312726
Nagaraju Bandaru1, Mohan Gandhi Bonthu1, Alluri Pavani Gayatri2, Shashikala Metri3, Perli Kranti Kumar1, Aneesha Addanki4, Srilaksmi Nallapaty5, Karri Swathi Priya6, Dodda Tulase Nadhreddy1, and P. N. S. Gowravi
1Department of Pharmacology and Pharmaceutical Quality Assurance, School of Pharmaceutical Sciences (SOPS), Sandip University, Nashik, Maharashtra, India
2Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India
3Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Hyderabad, Telangana, India
4Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India
5Department of Pharmaceutical Chemistry, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, India
6Department of Pharmacognosy, Srinivasarao College of Pharmacy, P.M. Palem, Visakhapatnam, Andhra Pradesh, India
7Department of Pharmacy Practice, Andhra University College of Pharmaceutical Sciences, Andhra University South Campus, Chinna Waltair, Andhra Pradesh, India
Corresponding author(s):
Nagaraju Bandaru, Department of Pharmacology and Pharmaceutical Quality Assurance, School of Pharmaceutical Sciences (SOPS), Sandip University, Nashik, Maharashtra 422213, India. E-mail: bnrajupharma@gmail.com
Abstract
Background
Alzheimer’s disease (AD) is a complex neurological disorder characterized by neuronal loss and progressive cognitive decline. The disease progression is influenced by both environmental and genetic factors. Recent research highlights the significant role of vitamin D in the pathological progression of AD.
Purpose
This review aims to comprehensively analyze the interplay between vitamin D and Alzheimer’s disease, focusing on its molecular mechanisms, epidemiological evidence, and therapeutic implications.
Methods
An extensive literature review was conducted to explore the molecular pathways by which vitamin D affects key pathological processes in AD, including amyloid-beta deposition, oxidative stress, neuronal inflammation, and tau phosphorylation. Epidemiological studies linking vitamin D status with AD prevalence and clinical outcomes were also analyzed, along with data from research trials investigating the efficacy of vitamin D supplementation in AD prevention and management.
Results
Vitamin D deficiency is associated with increased cognitive decline and heightened risk of developing AD. The review highlights the therapeutic potential of vitamin D supplementation in mitigating AD progression through its effects on pathological processes. However, challenges and controversies remain regarding the efficacy, optimal dosing regimens, and therapeutic strategies of vitamin D intake.
Conclusion
This review underscores the role of vitamin D as a modifiable factor and therapeutic target in Alzheimer’s disease. Further research is required to establish definitive dosing regimens and strategies to optimize the use of vitamin D in preventing and managing this debilitating neurological disorder.
Keywords: Vitamin D, progression, Alzheimer’s disease, amyloid-beta, therapeutic target