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    Volume 16, Issue 3

    The Quality Evaluation of Antibiotics for the Treatment of Diabetic Foot Ulcers in the Intensive Care Unit of Public Private Hospital, Semarang City

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    Gilang Rizki Al Farizi1, A.A.P. Paramitha Vidiani1, Fransisca Gloria1, Dewi Karlina1, and Enggar Budi Astuti2

    1Department of Pharmacy, STIKES Telogorejo Semarang, Semarang, Indonesia
    2Hospital Pharmacy Installation (IFRS), Roemani Muhammadiyah Semarang, Semarang, Indonesia
    Corresponding author(s):
    Gilang Rizki Al Farizi, Department of Pharmacy, STIKES Telogorejo Semarang, Jl. Puri Anjasmoro Raya, Kec. Semarang Barat, Kota Semarang, Jawa Tengah, Semarang 53411, Indonesia. Email: gilang_rizki@stikestelogorejo.ac.id

    Abstract

    Background Diabetic ulcers are infections caused by the loss of the deepest skin tissue on the feet of patients with diabetes mellitus. Appropriate treatment, such as antibiotic therapy, is necessary to prevent the spread of infection and antibiotic resistance.

    Objectives This study aims to evaluate the use of antibiotics to treat diabetic foot ulcers (DFU) qualitatively using Gyssens analysis in the intensive care units (ICUs).

    Materials and Methods The study was held retrospectively by analyzing the quality of antibiotics used with Gyssens. Data collection was held at Roemani Muhammadiyah Semarang Hospital, Semarang City. Subjects involved in this study included all ICU patients who were prescribed antibiotics from January 2020 until December 2022.

    Results The results showed that the highest of single-use antibiotics was Meropenem (7.14%), the dual antibiotic combination was Clindamycin plus Meropenem (7.14%) and a triple antibiotic combination was Metronidazole plus Ceftriaxone plus Ciprofloxacin (3.57%), Ceftriaxone plus Meropenem plus Levofloxacin (3.57%). The accuracy of antibiotic use based on Gyssens analysis was obtained from 41 prescriptions it was the category appropriate were 16 prescriptions (39.02%), inappropriate doses were six prescriptions (14.63%), too short use was 13 prescriptions (31.71%), and more effective antibiotics needed were six patients (14.63%).

    Conclusion The utilization rate among antibiotics for the treatment of DFU was deemed inappropriate. It was also necessary to perform a bacterial culture before deciding on the mode of administration.

    Keywords: Antibiotic, diabetic foot ulcer, Gyssens analysis, intensive care units

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