Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAs traditional laboratory animal use faces ethical and logistical constraints, the chick ileum has been experimented with as an alternate tissue for bioassays, which is crucial for drug discovery and pharmacology education. However, the absence of uniform bioassay protocols for chick ileum presents a significant challenge, impacting the accuracy and reliability of results in pharmacological studies.PurposeThe objective of this review was to compile existing data on chick ileum bioassays from published sources, aiming to enhance future experiments and contribute to the establishment of standardized methods for conducting these bioassays.MethodsWe conducted a systematic…
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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundInsomnia is a significant public health problem that can affect up to 50% of older adults. Pharmacological treatments are commonly used such as benzodiazepines (BZD) and related Z-drug zopiclone.PurposeThe objective of this study was to investigate the use of zopiclone under real-life clinical conditions.Materials and MethodsA retrospective review of older patients was conducted in a French geriatric hospital. The eligible participants included patients aged 65 years and older who had received zopiclone as a hypnotic. The presence of indication, the dosage and duration of zopiclone, the reevaluation of the treatment, the reason…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAlzheimer’s disease (AD) is a complex neurological disorder characterized by neuronal loss and progressive cognitive decline. The disease progression is influenced by both environmental and genetic factors. Recent research highlights the significant role of vitamin D in the pathological progression of AD.PurposeThis review aims to comprehensively analyze the interplay between vitamin D and Alzheimer’s disease, focusing on its molecular mechanisms, epidemiological evidence, and therapeutic implications.MethodsAn extensive literature review was conducted to explore the molecular pathways by which vitamin D affects key pathological processes in AD, including amyloid-beta deposition, oxidative stress, neuronal inflammation,…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundLow back pain is a pervasive and often debilitating musculoskeletal condition that affects millions of people worldwide. Low back pain affects 619 million globally (10%) and may rise to 843 million by 2050. It causes 8% years lived with disability and 4.6% disability-adjusted life years in India, with a 1.2%–2.3%. Ayurvedic interventions offer potential relief, specifically Panchaprasrutik Basti (bowel lavage/enema). This study investigates Basti’s therapeutic effects on low back pain.PurposeTo assess Panchaprasrutik Basti’s efficacy in reducing Katishula (low back pain) using the visual analog scale (VAS). Also, the efficacy of Panchaprasrutik Basti in…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. The aim of this study is to investigate the efficacy of interleukin-6 (IL-6) inhibitor antibodies as a therapeutic agent to combat severe COVID-19. Given the constant evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, the study aims to assess the potential of these inhibitors in adapting to new challenges and improving treatment outcomes. A comprehensive review of relevant literature was conducted using electronic databases such as Web of Science, PubMed, EMBASE, Scopus, and Google Scholar. The study analyzed the role of IL-6 inhibitors in combating SARS-CoV-2, focusing on…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Read Original Source
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. The aim of this study is to investigate the efficacy of interleukin-6 (IL-6) inhibitor antibodies as a therapeutic agent to combat severe COVID-19. Given the constant evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, the study aims to assess the potential of these inhibitors in adapting to new challenges and improving treatment outcomes. A comprehensive review of relevant literature was conducted using electronic databases such as Web of Science, PubMed, EMBASE, Scopus, and Google Scholar. The study analyzed the role of IL-6 inhibitors in combating SARS-CoV-2, focusing on…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. The aim of this study is to investigate the efficacy of interleukin-6 (IL-6) inhibitor antibodies as a therapeutic agent to combat severe COVID-19. Given the constant evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, the study aims to assess the potential of these inhibitors in adapting to new challenges and improving treatment outcomes. A comprehensive review of relevant literature was conducted using electronic databases such as Web of Science, PubMed, EMBASE, Scopus, and Google Scholar. The study analyzed the role of IL-6 inhibitors in combating SARS-CoV-2, focusing on…
Original Research Article Journal of Pharmacology and Pharmacotherapeutics Online First https://doi.org/10.1177/0976500X251313603 Bhashanjali Singh, Mamata Nakade, and Sidhi Sharma Department of Panchakarma, Dr. D. Y. Patil College of Ayurved and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India. Corresponding author(s): Mamata Nakade, Department of Panchakarma, Dr. D. Y. Patil College of Ayurved and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, Maharashtra 411018, India. E-mail: mamta.nakade@dpu.edu.in ABSTRACT Background Low back pain is a pervasive and often debilitating musculoskeletal condition that affects millions of people worldwide. Low back pain affects 619…
Journal of Pharmacology and Pharmacotherapeutics Online First Review Article https://doi.org/10.1177/0976500X241312726 Nagaraju Bandaru1, Mohan Gandhi Bonthu1, Alluri Pavani Gayatri2, Shashikala Metri3, Perli Kranti Kumar1, Aneesha Addanki4, Srilaksmi Nallapaty5, Karri Swathi Priya6, Dodda Tulase Nadhreddy1, and P. N. S. Gowravi 1Department of Pharmacology and Pharmaceutical Quality Assurance, School of Pharmaceutical Sciences (SOPS), Sandip University, Nashik, Maharashtra, India 2Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India 3Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Hyderabad, Telangana, India 4Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India 5Department of Pharmaceutical Chemistry, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, India 6Department of Pharmacognosy, Srinivasarao College of Pharmacy, P.M. Palem, Visakhapatnam, Andhra Pradesh, India 7Department…