Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print.
BackgroundInsomnia is a significant public health problem that can affect up to 50% of older adults. Pharmacological treatments are commonly used such as benzodiazepines (BZD) and related Z-drug zopiclone.PurposeThe objective of this study was to investigate the use of zopiclone under real-life clinical conditions.Materials and MethodsA retrospective review of older patients was conducted in a French geriatric hospital. The eligible participants included patients aged 65 years and older who had received zopiclone as a hypnotic. The presence of indication, the dosage and duration of zopiclone, the reevaluation of the treatment, the reason for discontinuation, and the combination with BZD were assessed.ResultsThe study included 30 subjects (mean age 84.6 ± 9.3 years), 90% of whom received zopiclone 3.5 mg and 10% zopiclone 7.5 mg. In 60% of cases, no indication of insomnia was found. At discharge, more patients received a combination of zopiclone and BZD. The drug reassessment was initiated in only nine patients.ConclusionThe treatment of insomnia with zopiclone is usually prescribed for long-term periods in older adults with less need for reevaluation. More long-term data on side effects and therapeutic efficacy are needed in routine clinical practice.