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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundNoni (Morinda citrifolia Linn.) fruit has a long history of traditional use for treating several health conditions, including symptoms of major depression and anxiety.PurposeThis study focused on evaluating the therapeutic potential of the …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundWe have reported that the renal kallikrein–kinin system is involved in the diuretic action of potassium or furosemide in rats.PurposeThe aim of this study was to investigate whether the renal kallikrein–kinin system is involved in the diuretic …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundPulmonary hypertension (PH) is a disorder of the pulmonary blood vessels that is often accompanied by other clinical conditions, which can lead to complications in cardiovascular and respiratory diseases. The clinical outcome of patients with PH …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundMedical students experience a heightened risk of depression and necessitate effective, low-side-effect interventions.PurposeThis study evaluates the efficacy of saffron in decreasing salivary cortisol levels and alleviating mild depressive …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundHypertension is a worldwide health issue and an independent risk factor for cardiovascular disease. Endothelial dysfunction is an important mechanism for its pathogenesis, thus compromising vascular homeostasis and causing vascular remodeling. …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundImmunotherapy has wholly changed how cancer is treated by using the body’s immune system to eliminate cancer cells. Cancer vaccines, chimeric antigen receptor T-cell (CAR-T) treatments, and immune checkpoint inhibitors (ICIs) are at the …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundSurgical wound healing remains challenging in the clinical setting, bedeviled by infection, inflammation, and dysfunctional tissue regeneration. Present treatments rely on dressings and anti-biotics, whose bioavailability and site-specific …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundSelective serotonin reuptake inhibitors (SSRIs), including fluoxetine and sertraline, are widely prescribed for depression due to their favorable safety profiles compared to older anti-depressants. However, these medications are associated with …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundDrug–drug interactions (DDIs) are a significant concern among cardiac inpatients, potentially impacting therapeutic outcomes and patient safety. Early identification and management of potential DDIs are crucial in preventing adverse events, …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundIntraoperative hypothermia is a common complication in elderly patients undergoing joint replacement surgery that can lead to adverse outcomes.PurposeThis study aimed to analyze the pertinent risk factors influencing intraoperative hypothermia …Read Original Source