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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundOsteoarthritis (OA) is the most common form of arthritis affecting the elderly and obese population, and requires long-term medical management. Inflammatory pathways, possibly initiated by tissue damage and stress are involved in the …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background/PurposeAlzheimer’s disease (AD) is a long-term neurodegenerative condition that leads to the gradual deterioration of nerve cells. The goal of this study is to use computational drug discovery (CDD) techniques to discover lead compounds that …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundChronic diseases present a significant health risk, and global medication adherence for these conditions remains insufficient. Understanding the factors that affect adherence is essential.PurposeThis study aims to better understand medication …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundTraditional teaching methods can pose challenges for learners, particularly when it comes to applying theoretical knowledge in practical settings. In contrast, Peyton’s four-step approach provides a structured, learner-centered framework that …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundHand hygiene is the key to prevent spread of infections in any health care setting. It is vital to understand and assess health care students knowledge and understanding towards hand hygiene so that effective infection control can be ensured….Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundOpioids have been an integral part of pain management for many years. With the increasing global burden of opioid dependence, the development of non-opioid therapies provides a new framework for pain management. Suzetrigine is a stepping stone …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundDoxorubicin (DX)-induced cardiotoxicity involves dose- and time-dependent myocardial injury driven by oxidative stress, mitochondrial dysfunction, and disrupted topoisomerase IIβ signaling, leading to progressive left ventricular dysfunction and …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundThe utilisation of vasoconstrictors like clonidine with local anaesthetics during subarachnoid blockade is a well-established practice.PurposeThis study aims to compare the effects of oral clonidine premedication versus placebo on the onset and …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundCancer is a complex condition defined by the uncontrolled growth and proliferation of cells. Brain neoplasms, both primary and secondary, present a rising global health burden. Newer classification integrates key molecular markers; IDH mutation, …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundIn Serbia, as well as worldwide, clinical trials are a significant and unavoidable part of the development of new medicines. There is limited research on prospective risk management in clinical trials in Serbia, underscoring the need for …Read Original Source