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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundChronic kidney disease (CKD) is a condition that deteriorates over time and causes the loss of nephrons, leading to impaired kidney function and finally bringing on end-stage renal disease (ESRD). As the world’s 12th biggest cause of mortality, …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundLifitegrast, a lymphocyte function-associated antigen-1 antagonist, was found to be useful in the treatment of psoriasis.PurposeThe study aimed to evaluate semisolid formulations of lifitegrast for their physicochemical and efficacy performance….Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundCancer has become the second leading cause of death among the Indian population.PurposeThe purpose of the research was to elucidate and compare the suppressive impact on cell proliferation of metformin, teneligliptin, and canagliflozin on MCF-7 …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAfter the restoration of COVID-19 lockdowns and the relaxation of general public health restrictions, an upswing in the incidence of respiratory diseases was observed. Respiratory illnesses have been soaring among children with the easing of …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundThe Internet of Things (IoT) and wireless sensor networks (WSNs) are now being explored and used in various sectors, thanks to recent technological advancements.PurposeThe healthcare sector is one of the areas we will examine in this research. …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRheumatoid arthritis (RA) affects nearly 4% of the world’s population, along with an increasing rate of new cases.PurposeThe current work was focused on investigating the anti-arthritic efficacy of theCurcuma xanthorrhizarhizome extract (CXRE) …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Epidermal growth factor receptor (EGFR) plays an active role during the progression of oral squamous cell carcinoma (OSCC). OSCC is the most common head and neck cancer. Cetuximab, which is an inhibitor of EGFR, was approved by the Food and Drug …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundPharmacogenomics aims to optimise drug therapy based on genetic makeup, but traditional clinical trial design faces challenges with complexity, cost and data integration.PurposeThis study explores integrating generative artificial intelligence (AI), specifically large language models (LLMs) like Llama3 8B, Mistral 7B v0.3 and Phi-3 Mini 3.8B, into pharmacogenomics clinical trial design through Retrieval-Augmented Generation frameworks and local knowledge bases to address the challenges.Materials and MethodsWe conducted a comparative analysis of LLMs, evaluating the accuracy, relevancy, response time and operational efficiency with a case study that assessed LLMs’ capacity to address key trial design…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: Lumbar canal stenosis (LCS) is a degenerative spinal condition causing narrowing of the spinal canal, leading to nerve compression. Symptoms include pain, stiffness, tingling, numbness, and difficulty walking, which worsen with standing and improvement with sitting. Conventional treatments offer symptomatic relief, while surgery carries risks and a high recurrence rate. Ayurveda provides a holistic, non-surgical approach through Shodhana (purification) and Shamana Chikitsa (palliative care). Purpose: This study evaluates the effectiveness of Ayurvedic therapies, including Panchakarma and oral medications, in managing lumbar canal stenosis. Methods: A 68-year-old male presented with lower back…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundVaricocelectomy is one of the main complications that, if left untreated, results in male infertility. Various approaches have been adopted to manage it, but there is a variation in the consensus.PurposeThis systematic review aims to summarize the evidence on the various clinical trials and post-varicocelectomy recovery for patients consuming different supplements or regimens.Materials and MethodsAn organized and systematic literature search was conducted in five electronic databases from their inception till 2021. Upon applying the PICOT format and student inclusion criteria, only n = 13 articles fulfilled the eligibility criteria and were selected…