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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundProlonged elevation of thyroid hormone levels leads to cardiomyocyte hypertrophy, tissue fibrosis, and altered cardiac electrophysiology. Abnormal activation of the Signal Transducer and Activator of Transcription (STAT) signaling pathway plays …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Metabolic disorders, including diabetes mellitus and obesity, continue to pose a major public health challenge. Diabetes is a disorder of glucose metabolism that can be associated with vestibular dysfunction. Traditionally, vestibular stimulation (VS) is …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundDrug Utilisation Review (DUR) and the Medication Regimen Complexity Index (MRCI) are emerging tools to optimise prescribing, minimise regimen burden and improve outcomes in gynaecological pharmacotherapy. However, their application in routine …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundType 2 diabetes (T2D)-induced glucose toxicity leads to the development of several pathological conditions in the vital organs. Diabetic nephropathy (DN) is a severe microvascular condition of T2D.PurposeHyperglycemia associated with free …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundHeat stress (HS) is the body’s inability to manage internal heat efficiently. It impairs endothelial function, causes oxidative stress, and disrupts nitric oxide (NO) signaling, highlighting the downstream effects of endothelial dysfunction, …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAdrenocortical carcinoma (ACC) is an aggressive malignancy with limited therapeutic options, and microRNA (miRNA)-based strategies such as hsa-miR-466 have emerged as potential regulatory interventions.PurposeThis study aimed to investigate the …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundNigella sativais the source of thymoquinone (TQ), an active phenolic compound with numerous pharmacological properties, including anti-tumor, anti-angiogenic, and antioxidant activities. Nevertheless, the mechanism by which TQ exerts its …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRepurposing of a hydroxylmethylglutaryl coenzyme A reductase inhibitor like simvastatin has gained significant interest in oncologic treatment owing to the pleiotropic effects. However, the role of simvastatin in inhibiting epithelial-…Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Competency-based medical education (CBME) marks a paradigm shift in medical training by prioritizing outcomes over time-based progression and focusing on clearly defined competencies aligned with societal needs. Faculty serve as critical agents of this …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRegional anaesthesia is widely preferred for upper limb surgeries, particularly those performed below the elbow; however, the limited duration of action of local anaesthetics remains a clinical challenge. The addition of adjuvants such as …Read Original Source