Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRitlecitinib (RIT) is a novel kinase inhibitor with promising therapeutic applications in the treatment of autoimmune disease alopecia areata. Accurate quantification of RIT in biological matrices is essential for pharmacokinetic studies and drug development.ObjectivesThis study aims to develop and validate a sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitation of RIT in rat plasma and to apply this method in a pharmacokinetic study.Materials and MethodsA sensitive and selective LC-MS/MS method was developed in a AB Sciex QTRAP 5500 coupled with Shimadzu Prominence LC-20AD UFLC (ultra-fast liquid chromatography) System…
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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: The most common condition that restricts movement is low back pain, which is particularly common in the most productive years of life. Sciatica syndrome accounts for 40% of patients’ severe lower back pain. Psychological strain places excessive strain on the spinal column and is a major contributing factor to the development of sciatica and lower back pain.Purpose: The illness indicated in Ayurveda has symptoms and signs similar to “Sciatica” in modern, contemporary medicine. In clinical practice, Gridhrasi (Sciatica), the conditions stated in Ayurveda are comparable to those treated in contemporary medicine.Methods:…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundMachine Learning-powered Internet of Medical Things (MLIoMT) is a burgeoning framework poised to transform healthcare, particularly in the timely identification of heart disease.PurposeThis article proposes an innovative MLIoMT structure aimed at leveraging machine learning (ML) algorithms for heart disease detection.MethodsThrough the integration of wearable sensors, mobile applications, cloud computing, and advanced ML techniques, MLIoMT enables continuous monitoring of vital signs and cardiac health indicators in real time. By analyzing this data stream, abnormalities indicative of heart disease can be detected early, facilitating timely intervention and personalized healthcare recommendations. The MLIoMT framework employs…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundPlants are attractive sources of anti-cancer agents. However, there is limited data about the anti-cancer potential of Ethiopian medicinal plants traditionally used for the treatment of cancer.PurposeTo screen the cytotoxicity of 26 Ethiopian medicinal plants against breast cancer cells (MCF-7) and to demonstrate the potential consistent cytotoxicity of the six most active extracts against prostate cancer cell line (PC-3) and neuroblastoma (SH-SY5Y). Furthermore, the mode of action of the most active extracts should be investigated.MethodsTwenty-six Ethiopian medicinal plants were collected from 12 sites and extracted using 80% methanol through maceration. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAs traditional laboratory animal use faces ethical and logistical constraints, the chick ileum has been experimented with as an alternate tissue for bioassays, which is crucial for drug discovery and pharmacology education. However, the absence of uniform bioassay protocols for chick ileum presents a significant challenge, impacting the accuracy and reliability of results in pharmacological studies.PurposeThe objective of this review was to compile existing data on chick ileum bioassays from published sources, aiming to enhance future experiments and contribute to the establishment of standardized methods for conducting these bioassays.MethodsWe conducted a systematic…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundInsomnia is a significant public health problem that can affect up to 50% of older adults. Pharmacological treatments are commonly used such as benzodiazepines (BZD) and related Z-drug zopiclone.PurposeThe objective of this study was to investigate the use of zopiclone under real-life clinical conditions.Materials and MethodsA retrospective review of older patients was conducted in a French geriatric hospital. The eligible participants included patients aged 65 years and older who had received zopiclone as a hypnotic. The presence of indication, the dosage and duration of zopiclone, the reevaluation of the treatment, the reason…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAlzheimer’s disease (AD) is a complex neurological disorder characterized by neuronal loss and progressive cognitive decline. The disease progression is influenced by both environmental and genetic factors. Recent research highlights the significant role of vitamin D in the pathological progression of AD.PurposeThis review aims to comprehensively analyze the interplay between vitamin D and Alzheimer’s disease, focusing on its molecular mechanisms, epidemiological evidence, and therapeutic implications.MethodsAn extensive literature review was conducted to explore the molecular pathways by which vitamin D affects key pathological processes in AD, including amyloid-beta deposition, oxidative stress, neuronal inflammation,…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundLow back pain is a pervasive and often debilitating musculoskeletal condition that affects millions of people worldwide. Low back pain affects 619 million globally (10%) and may rise to 843 million by 2050. It causes 8% years lived with disability and 4.6% disability-adjusted life years in India, with a 1.2%–2.3%. Ayurvedic interventions offer potential relief, specifically Panchaprasrutik Basti (bowel lavage/enema). This study investigates Basti’s therapeutic effects on low back pain.PurposeTo assess Panchaprasrutik Basti’s efficacy in reducing Katishula (low back pain) using the visual analog scale (VAS). Also, the efficacy of Panchaprasrutik Basti in…
Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. The aim of this study is to investigate the efficacy of interleukin-6 (IL-6) inhibitor antibodies as a therapeutic agent to combat severe COVID-19. Given the constant evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, the study aims to assess the potential of these inhibitors in adapting to new challenges and improving treatment outcomes. A comprehensive review of relevant literature was conducted using electronic databases such as Web of Science, PubMed, EMBASE, Scopus, and Google Scholar. The study analyzed the role of IL-6 inhibitors in combating SARS-CoV-2, focusing on…
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