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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundDown syndrome (DS), caused by trisomy 21, is characterized by chronic oxidative stress resulting from overexpression of the superoxide dismutase 1 (SOD1) gene without a proportional increase in downstream antioxidant enzymes such as glutathione …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundBuprofezin, a thiadiazine insecticide globally recognized as a molting inhibitor, is widely used for controlling whitefly and other insect pests.PurposeThis study investigated the impacts of sub-lethal buprofezin concentrations (0.15, 0.30, and …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare yet debilitating neuropathy characterized by chronic inflammation, demyelination, and axonal degeneration. Current treatments, including corticosteroids, intravenous …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundDoxorubicin (DOX), an anthracycline-based chemotherapeutic agent, has been widely used as a first-line treatment for several cancers, including hematological and solid tumors, but its clinical utility is limited by severe cardiotoxicity and …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundOsteoarthritis (OA) is the most common form of arthritis affecting the elderly and obese population, and requires long-term medical management. Inflammatory pathways, possibly initiated by tissue damage and stress are involved in the …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background/PurposeAlzheimer’s disease (AD) is a long-term neurodegenerative condition that leads to the gradual deterioration of nerve cells. The goal of this study is to use computational drug discovery (CDD) techniques to discover lead compounds that …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundChronic diseases present a significant health risk, and global medication adherence for these conditions remains insufficient. Understanding the factors that affect adherence is essential.PurposeThis study aims to better understand medication …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundTraditional teaching methods can pose challenges for learners, particularly when it comes to applying theoretical knowledge in practical settings. In contrast, Peyton’s four-step approach provides a structured, learner-centered framework that …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundHand hygiene is the key to prevent spread of infections in any health care setting. It is vital to understand and assess health care students knowledge and understanding towards hand hygiene so that effective infection control can be ensured….Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundOpioids have been an integral part of pain management for many years. With the increasing global burden of opioid dependence, the development of non-opioid therapies provides a new framework for pain management. Suzetrigine is a stepping stone …Read Original Source