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Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundAfter the restoration of COVID-19 lockdowns and the relaxation of general public health restrictions, an upswing in the incidence of respiratory diseases was observed. Respiratory illnesses have been soaring among children with the easing of …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundThe Internet of Things (IoT) and wireless sensor networks (WSNs) are now being explored and used in various sectors, thanks to recent technological advancements.PurposeThe healthcare sector is one of the areas we will examine in this research. …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRheumatoid arthritis (RA) affects nearly 4% of the world’s population, along with an increasing rate of new cases.PurposeThe current work was focused on investigating the anti-arthritic efficacy of theCurcuma xanthorrhizarhizome extract (CXRE) …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Epidermal growth factor receptor (EGFR) plays an active role during the progression of oral squamous cell carcinoma (OSCC). OSCC is the most common head and neck cancer. Cetuximab, which is an inhibitor of EGFR, was approved by the Food and Drug …Read Original Source

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundPharmacogenomics aims to optimise drug therapy based on genetic makeup, but traditional clinical trial design faces challenges with complexity, cost and data integration.PurposeThis study explores integrating generative artificial intelligence (AI), specifically large language models (LLMs) like Llama3 8B, Mistral 7B v0.3 and Phi-3 Mini 3.8B, into pharmacogenomics clinical trial design through Retrieval-Augmented Generation frameworks and local knowledge bases to address the challenges.Materials and MethodsWe conducted a comparative analysis of LLMs, evaluating the accuracy, relevancy, response time and operational efficiency with a case study that assessed LLMs’ capacity to address key trial design…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: Lumbar canal stenosis (LCS) is a degenerative spinal condition causing narrowing of the spinal canal, leading to nerve compression. Symptoms include pain, stiffness, tingling, numbness, and difficulty walking, which worsen with standing and improvement with sitting. Conventional treatments offer symptomatic relief, while surgery carries risks and a high recurrence rate. Ayurveda provides a holistic, non-surgical approach through Shodhana (purification) and Shamana Chikitsa (palliative care). Purpose: This study evaluates the effectiveness of Ayurvedic therapies, including Panchakarma and oral medications, in managing lumbar canal stenosis. Methods: A 68-year-old male presented with lower back…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundVaricocelectomy is one of the main complications that, if left untreated, results in male infertility. Various approaches have been adopted to manage it, but there is a variation in the consensus.PurposeThis systematic review aims to summarize the evidence on the various clinical trials and post-varicocelectomy recovery for patients consuming different supplements or regimens.Materials and MethodsAn organized and systematic literature search was conducted in five electronic databases from their inception till 2021. Upon applying the PICOT format and student inclusion criteria, only n = 13 articles fulfilled the eligibility criteria and were selected…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundRitlecitinib (RIT) is a novel kinase inhibitor with promising therapeutic applications in the treatment of autoimmune disease alopecia areata. Accurate quantification of RIT in biological matrices is essential for pharmacokinetic studies and drug development.ObjectivesThis study aims to develop and validate a sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantitation of RIT in rat plasma and to apply this method in a pharmacokinetic study.Materials and MethodsA sensitive and selective LC-MS/MS method was developed in a AB Sciex QTRAP 5500 coupled with Shimadzu Prominence LC-20AD UFLC (ultra-fast liquid chromatography) System…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. Background: The most common condition that restricts movement is low back pain, which is particularly common in the most productive years of life. Sciatica syndrome accounts for 40% of patients’ severe lower back pain. Psychological strain places excessive strain on the spinal column and is a major contributing factor to the development of sciatica and lower back pain.Purpose: The illness indicated in Ayurveda has symptoms and signs similar to “Sciatica” in modern, contemporary medicine. In clinical practice, Gridhrasi (Sciatica), the conditions stated in Ayurveda are comparable to those treated in contemporary medicine.Methods:…

Journal of Pharmacology and Pharmacotherapeutics, Ahead of Print. BackgroundMachine Learning-powered Internet of Medical Things (MLIoMT) is a burgeoning framework poised to transform healthcare, particularly in the timely identification of heart disease.PurposeThis article proposes an innovative MLIoMT structure aimed at leveraging machine learning (ML) algorithms for heart disease detection.MethodsThrough the integration of wearable sensors, mobile applications, cloud computing, and advanced ML techniques, MLIoMT enables continuous monitoring of vital signs and cardiac health indicators in real time. By analyzing this data stream, abnormalities indicative of heart disease can be detected early, facilitating timely intervention and personalized healthcare recommendations. The MLIoMT framework employs…